头孢菌素C钠溶液膜超滤分离工艺的研究  

Study on the Membrane Ulfiltration Separation Process of Cephalosporin C Sodium Solution

作　　者：曹云峰[1] 鲍建芝[2] 吴兆亮[2] 张晓艳[1] 董荣梅[1] 

机构地区：[1]石药集团河北中润制药有限公司,河北石家庄050041 [2]河北工业大学生物工程学院,天津300130

出　　处：《河北化工》2005年第3期59-61,共3页Hebei Chemical Industry

摘　　要：以头孢菌素C钠盐的水溶液为对象设计实验,考察板式膜的膜通量和溶质透过率的衰减现象,以及钠离子对膜的影响。衰减的主要原因是膜表面吸附钠离子以及在膜表面形成浓差极化层。原液浓度影响膜通量是间接的,其外在宏观表现为原液浓度高、膜的处理量大、处理时间长和钠离子含量高都将加剧膜通量和溶质透过率的衰减。The decline of the flux of the flat membrane and the permeation coeffecient of solute,and the influence of sodium ion to the membrane,with cephalosprin C sodium solution as a model solution, has been investigated.The decline is caused mainly by sodium ion adsorbed on the membrane and concentration polarization on the membrane surfacee.The effect of the concentration in recirculating solution is an indirect factor. The external behaviors are those of high concentration in recirculating solution,large permeating volume, long operating time and high sodium ion concentration will accumulate the decline of the flux and the permeation coeffecient of solute.

关 键 词：膜 通量 衰减 污染 溶质透过率 

分 类 号：R978.11[医药卫生—药品] TQ028.8[医药卫生—药学]