晶体和冷血停跳液在心脏直视手术中的临床应用  

The Clinical Effects of CCP or BCP on Open Heart Disease

作　　者：黄一东[1] 王志刚[1] 林群[1] 

机构地区：[1]广东医学院附属医院心胸外科,湛江524001

出　　处：《齐齐哈尔医学院学报》2005年第5期484-485,共2页Journal of Qiqihar Medical University

摘　　要：目的比较晶体和冷血停跳液在心脏直视手术中的临床应用效果。方法在221例心脏直视手术中分别用晶体停跳液(CCP组、157例)和冷含血停跳液(BCP组、64例)灌注,并进行心肌ATP、超微结构和临床比较研究,以观察冷含血停跳液对心肌保护的作用及机制。结果1)开放主动脉再灌注10min时,BCP组ATP下降幅度是CCP组的46%;2)电镜观察示BCP组在细胞水肿、肌节挛缩及线粒体损伤等方面较CCP组轻;3)BCP组心搏恢复有力平稳,对正性肌力药物需求减少。结论在心肌缺血期间,BCP组能维持细胞正常代谢的需要,保证内环境平稳,减少缺血心肌的损害,在心肌保护方面有明显优越性。BCP心肌保护的效果优于CCP。Objective To compare the clinical effects of crystal cardioplegia (CCP)or blood cardioplegia (BCP) on open heart disease. Methods CCP or BCP were used in 157 and 64 patients with open heart disease respectively, and we compared the contents of myocardial ATP and micro-structure of myocardium in CCP group with that of in BCP group.Results 1) The content of ATP in BCP group decreased about 46% more than in CCP after 10 minute with aortic reperfusion.2)Cell edema, sarcomere contracture and mitochondria injury were lighter in BCP group than in CCP group.3)The recovery of heart beat were more powerful and stable in BCP group than in CCP group. Conclusions The effect of protecting myocardium with BCP on open heart disease are better than that with CCP

关 键 词：心脏直视 手术中 冷血停跳液 晶体 临床应用效果 临床比较研究 心肌保护 心肌ATP 动脉再灌注 线粒体损伤 BCP CCP 超微结构 电镜观察 药物需求 正性肌力 心肌缺血 正常代谢 缺血心肌 内环境 优越性 细胞 平稳 

分 类 号：R654.2[医药卫生—外科学] R657.4[医药卫生—临床医学]