~(99m）Tc－MIBI心肌灌注断层显像潘生丁试验对冠心病诊断及疗效观察的临床价值  

THE CLINICAL VALUE OF DIPYRIDAMOLE ￣(99m)TC-MIBI MYOCARDIAL PERFUSION TOMOGRAPHY FOR DIAGNOSING CORONARY HEART DISEASE AND ASSESSING THERAPEUTIC EFFECT

作　　者：岳明纲[1] 高伯山[1] 齐桂英[1] 梁铁军[1] 张彩群[1] 杨志健[1] 王静毅[1] 

机构地区：[1]北京医科大学人民医院核医学科,北京医科大学人民医院心内科

出　　处：《中华核医学杂志》1994年第2期73-75,共3页Chinese Journal of Nuclear Medicine

摘　　要：对７０例９９ｍＴｃ－ＭＩＢＩ心肌灌注断层显像潘生丁试验（ＣＴＤ）及ＥＣＧ结果与冠状动脉造影（ＣＡ）进行对照分析，结果表明：ＣＴＤ检测冠状动脉管腔狭窄≥５０％病变的灵敏度和特异性分别是８８％和９３％，明显高于ＥＣＧ（５２％和７７％），检出左前降支（ＬＡＤ）、左回旋支（ＬＣＸ）及右冠状动脉（ＲＣＡ）病变的灵敏度分别为８２％、８４％及８３％；检测冠状动脉单支病变的灵敏度为８２％，检出轻、中、重度狭窄的灵敏度分别是４４％、８１％、１００％．对１７例经皮腔内冠状动脉成形术（ＰＴＣＡ）患者的术前术后ＣＴＤ结果进行了分析．结果表明ＣＴＤ对于诊断冠心病的灵敏度和特异性都很高，对筛选ＰＴＣＡ术前病人以及手术疗效评价和追踪观察有很重要的临床价值．Abstract In this study, the results of EKG and 99mTc labelled MIBI radionuclide myocardial tomography after giving dipyridamole (99mTc-MIBI SPECT) intravenously in 70 cases of coronary artery disease were compared to the findings by coronary angiography. It was found that the sensitivity and specificity of 99mTc-MIBI SPECT for coronary artery stenosis of more than 50% were 88% and 93%,respectively, vs. 52% and 77%, respectively, found by EKG. The differences were both statistically significant. The sensitivity of 99mTc-MIBI SPECT in detecting lesion of LAD, LCX and RA was 82%, 84% and 83%, respectively. Its prospective sensitivity for detection of single vessel disease was 82%. In addition, the results of 99mTc-MIBI SPECT performed pre-PTCA compared to those of post-PTCA in 17 cases suggest that 99mTc-MIBI SPECT has high sensitivity and specificity in the diagnosis of coronary artery disease. It is also a good method in screening the candidates for PTCA.

关 键 词：冠心病 放射性核素 显像 潘生丁 

分 类 号：R541.4[医药卫生—心血管疾病]