白细胞介素－1受体拮抗剂对肺间质纤维化的影响  

The effect of IL-1 receptor antagonist onbleomycin-induced Pulmonary fibrosis

作　　者：何冰[1] 赵桂荣[1] 刘新民[1] 阙呈立 刘青 毛毅敏 郝青林 

机构地区：[1]北京医科大学第一临床医学院

出　　处：《中华结核和呼吸杂志》1994年第1期21-23,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：白细胞介素－１（ＩＬ－１）是一种具有多种生物活性的细胞因子，它参与了肺间质纤维化形成的过程。白细胞介素－１受体拮抗剂（ＩＬ－１ｒａ）能和ＩＬ－１竞争靶细胞表面受体，阻断ＩＬ－１的效应。为了探索治疗肺间质纤维化的新途径，我们在博莱霉素所致大鼠肺间质纤维化模型上，气管灌注重组人ＩＬ－１ｒａ，观察病理变化、胶原蛋白量以及转化牛长因子－βｍＲＮＡ在肺内表达的变化，评价ＩＬ－１ｒａ对肺间质纤维化形成的影响，结果发现这些指标在ＩＬ－１ｒａ治疗组和对照组间并无明显差异。nterleukin-1 (IL-1) is a cytokine with diverseKiological activities. It can serve as a fibroblast (FB)growth factor which involves in the development ofpulmonary fibrosis. IL- 1 receptor antagonist (IL- 1ra)can compete with IL-1 for occupancy of surfaceraseptors of target cells without agonist effect. In or-der to find a new method to treat pulmonary fibrosis,we investigated the effect of recombinant humanIL-1ra on the development of pulmonary fibrosis byevaluating collagen content, histological change, andTGF-βmRNA expression in the rats bleomycin-in-duced pulmonary fibrosis. The results indrcate are thatthere are no significant difference between the IL-1ratreated group and the control group.

关 键 词：白细胞介素1 受体 肺纤维化 

分 类 号：R563.13[医药卫生—呼吸系统]