TNF-α在疟原虫感染中的作用  

Role of TNF-α on the Infection of Malaria Parasites

作　　者：陈克强[1] 宋关鸿[2] 

机构地区：[1]上海交通大学农业与生物学院,上海201101 [2]第二军医大学病原生物学教研室,上海200433

出　　处：《上海交通大学学报（农业科学版）》2005年第2期207-212,共6页Journal of Shanghai Jiaotong University(Agricultural Science)

摘　　要：疟原虫感染后,诱导宿主前炎症细胞因子,TNF-α表达的疟原虫毒素是一类具有糖基磷脂酰肌醇(GPI)样结构的物质,其活性结构至少部分是保守性的。TNF-α表达的量在适宜范围内,对疟原虫有抑制作用,过度表达则造成宿主的病理损害,但病理损害的程度与疟原虫不同种、株的生物学特性密切相关。本文还对多种细胞因子在TNF-α的诱导和功能方面的协同、抑制和调节作用进行了综述。The expression of TNF- α , a kind of Pre- inflammatory cytokin es , can be induced by a component of malaria parasites, which could be a malaria- specific form of glycosyphosphatidylinositol(GPI) that includes acylation of th e inositol. The increased level of the constitutive expression of TNF- α cause s marked suppression of parasitaemia, but the over- expression of TNF- α cou ld make pathological damage to tissues of the host. This pathological changes is associated with the biological feature of malaria species. Regulation of other cytokines on the expression of TNF- α were also described.

关 键 词：TNF-Α 疟原虫 感染 糖基磷脂酰肌醇 细胞因子 生物学特性 活性结构 适宜范围 抑制作用 过度表达 调节作用 保守性 宿主 诱导 损害 病理 毒素 

分 类 号：S858.315.9[农业科学—临床兽医学] Q255[农业科学—兽医学]