气道上皮对维拉帕米解痉作用的影响  

Airway epithelium affects relaxing effect of vera-pamil

作　　者：甘立平[1] 凌培基[1] 

机构地区：[1]北京军区总医院,第三军医大学大坪医院

出　　处：《中华结核和呼吸杂志》1994年第4期223-226,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

摘　　要：气道高反应性疾病的特点是气道非特异性过敏，平喘药物疗效不佳和气道上皮损害。后者在疾病过程中的作用日益受到重视。笔者用豚鼠离体气管实验证实：①去上皮后气道对乙酰胆碱（Ａｃｅｔｙｌｃｈｏｌｉｎｅ，Ａｃｈ）反应性增加而对维拉帕米（Ｖｅｒａｐａｍｉｌ，Ｖｐ）的敏感性降低；②上皮源松弛因子（ＥｐｉｔｈｅｌｉｕｍＤｅｒｉｖｅｄＲｅｌａｘｉｎｇＦａｃｔｏｒ，ＥｐＤＲＦ）参与了这一过程；③ＥｐＤＲＦ不是环氧化酶产物。The characteristic features of airway hyperreactiv-ity disease are non-specific hyperresponsiveness,in-sensitive to spasmolysant and damage of epithelium.In our experiment ,we measured the tension change ofisolated trachea smooth muscle of guinea pig in react-ing to acetylcholine and verapamil. It confirmed that①the removal of epithelium increases the reactivity ofpreparations to acetylcholine and reduces the eflect ofverapamil,②in above process the epithelium-derivedrelaxing factor(EpDRF)had participated in airwayhyperreactivity and③EpDRF was not derived frommetablism of cyclooxygenase.

关 键 词：气道 上皮 气道高反应性 维拉帕米 

分 类 号：R965[医药卫生—药理学]