老年人多器官功能衰竭时免疫功能的变化  

Changes of immunological functions in elderly with multiple organ failure

作　　者：范利[1] 王士雯[1] 张遵一[1] 李求是[1] 贾万钧 韩志涛[1] 

机构地区：[1]中国人民解放军总医院

出　　处：《中华老年医学杂志》1994年第1期18-21,共4页Chinese Journal of Geriatrics

摘　　要：对４１例老年多器官功能衰竭（ＭＯＦＥ）患者进行了多项免疫功能指标监侧，并与健康组进行比较。结果表明：ＭＯＦＥ组的Ｔ细胞功能、白细胞吞噬活性、血浆纤维结合素明显降低（Ｐ＜０．０１），Ｃ－反应蛋白、过敏毒素活性明显增高（Ｐ＜０．０１），且随病情的好转、恶化而发生明显的变化。ＭＯＦＥ死亡组部分患者病情恶化时的免疫功能指标变化与存活组病情好转时比较，差异有显著性（Ｐ＜０．０１）。提示免疫功能低下和紊乱是老年人易发生感染、导致ＭＯＦＥ的主要因素，而且免疫功能的损伤程度与ＭＯＦＥ病情严重程度密切相关。因此认为，上述免疫功能指标可做为早期判断ＭＯＦＥ病情及预后的有意义的预警指标。Abstract Forty-one elderly patients aged 60-90 years with multiple organ faihire (MOFE) were studied for their immunological functions, including mitogenesis of T cells to PHA, phatoirocytosis of leukocytes determined by chemiluminescence (CL), serum C-reactive protein (CRP), serum fibronectin (Fn) and C5a activity. The results showed that T-cell functions, phagocytosis of leukocytes Fn level were decreased markedly and CRP as well as serum C5a activity were much higher in the MOFE than those of normal control group (P<0.01).Further more, all these changes corresponded well with the severity of the MOFE. This study implies that the immunodeficiency may play an important role in the development of MOFE. The functional state for host immune system is closely related to the prognosis of MOFE. Monitoring immune function could be a significantly index for determination of prognosis.

关 键 词：多器官衰竭 免疫学 老年人 

分 类 号：R59[医药卫生—内科学]