老年鼠肾线粒体的老化及其药物防护  

The protective effect of drugs on the aging of renal mitochondria in aged rats

作　　者：李晓玫[1] 王海燕[1] 李丽英[1] 毛亚文[1] 韩可汉[1] 耿琳[1] 韩进 李美花 张晓英 余霞君 

机构地区：[1]北京医科大学肾脏疾病研究所,北京医科大学泌尿研究所,中国人民解放军总医院老年心肾科

出　　处：《中华老年医学杂志》1994年第3期168-171,共4页Chinese Journal of Geriatrics

基　　金：国家青年自然科学基金

摘　　要：通过观察应用枸杞多糖、维生素Ｅ－Ｃ合剂等抗衰老药物后，老年鼠肾细胞线粒体超微结构、ＡＴＰ合成量以及脂质过氧化产物丙二醛水平的改变，发现老年鼠肾线粒体的结构和功能变化伴随着自由基代谢产物丙二醛的增高，老年鼠肾细胞线粒体ＡＴＰ合成量为１２０．３８±１６．７２ｎＭ／ｍｇＰｒ·ｍｉｎ，较青年组低１８．７５ｎＭ／ｍｇＰｒ·ｍｉｎ；而肾组织丙二醛为３０．４０±６．６６μｇ／１００ｍｇ湿重，是青年组的２．４倍。长期服用维生素Ｅ－Ｃ合剂或枸杞多糖均可在一定程度上对抗自由基的作用，使肾组织丙二醛水平下降，预防线粒体老化，使其功能有所改善。Abstract To study the protective effect of Vit-E. C and Lycium Barbarum Polysaccharide (LBP) on the aging of renal mitochondria, the mitochondrial ultrastructure and ATP synthetic content in renal cortex and MDA level of the aged rats were observed and compared with those of young rats. It was found that decreased ATP synthetic content and abnormal size and structure of renal mitochondria were accompanied by a significantly increased MDA level in aged rats. The morphological changes of renal mitochondria in aged rats without medicine included the malformation and degenerative changes. After being given Vit-E. C or LBP for two months, the ATP synthetic content of renal mitochondria increased notably and the MAD level decreased notably. The results suggest that long term use of drugs such as Vit-E. C or LBP may have effect against free radicals, cause lowering of MDA level in renal tissue, prevent mitochondria from aging and improve their function.

关 键 词：线粒体 肾 衰老 枸杞多糖 药理学 

分 类 号：R339.38[医药卫生—人体生理学]