新生儿乙型肝炎疫苗免疫持久性观察及再免研究  

Long-term Efficacy of Hepatitis B Vaccine in Newborn and Revaccination Study

作　　者：陈惠峰[1] 郭志宏[1] 张友金 王振海[1] 杨介者[1] 陶志华 顾卯官 曹家穗 吴祖云[1] 王文刚[1] 钱本立 姚军[1] 居全弟 许荣全 周民[1] 

机构地区：[1]浙江省卫生防疫站,平湖市卫生防疫站,嘉兴市卫生防疫站

出　　处：《中华流行病学杂志》1994年第2期76-79,共4页Chinese Journal of Epidemiology

摘　　要：新生儿经乙型肝炎（乙肝）疫苗１０μｇ３针全程免疫接种４、５年后，抗－ＨＢｓ阳性率分别为８２．５４％和７２．０３％。其抗－ＨＢｓ低滴度（≥１０～９９ｍＩＵ／ｍｌ）占４４．６１％，中等滴度（≥１００～９９９ｍＩＵ／ｍｌ）占３２．３４％，最高值为８５７ｍＩＵ／ｍｌ。对抗－ＨＢｓ＜１０ｍＩＵ／ｍｌ与≥１０ｍＩＵ／ｍｌ的各组予以乙型肝炎疫苗１０μｇ１剂再免，再免后１个月抗－ＨＢｓ大幅度升高，３个月时－ＨＢｓ开始回落，６个月时抗－ＨＢｓ大幅度下降，至１２个月左右时抗－ＨＢｓ逐趋于再免前的水平。本文提示国产乙型肝炎疫苗具良好的免疫效果，５～７年内不必普遍性再免。对－ＨＢｓ＜１０ｍＩＵ／ｍｌ的儿童再免后有一定裨益，但持续时间较短。wo-hundred and Sixty-nine newborns were followed up for 4 and 5 yearsafter completion of vaccination(10μg×3).The anti-HBs positive rates remained 82.54%and 72.03%,respectively. The low-leveltiter(≥10～99 mIU/ml)made up 44.61%,and the medium-level titer(≥100～999mIU/ml) 32.34%.The highest titer was 857mIU/ml.A 10μg dose of hepatitis B vac- cine was given to these chidren.Theanti-HBs level went up greatly in thefirst month after revaccination,but star-ted to drop in the third month,dec-reased rapidly in the sixth month,and inthe twelveth montb the level trended torestore the level before revaccination.This paper indicated that the home-made hepatitis B vaccine was effective.Revacci-nation was not necessary within 5～7years after initial vaccination.Revaccina-tion to children whose anti-HBs levelwas<10mIU/ml was beneficial but the anti- HBs persistence was short.

关 键 词：乙型肝炎 疫苗 免疫 持久性 新生儿 

分 类 号：R722.139[医药卫生—儿科]