应用ELISA法评价狂犬病疫苗免疫后的血清和流行病学效果  

Using ELISA to Evaluate the Serologic and Epidemiologic Effect following Rabies Vaccination

作　　者：宋慧军 李伟 单丽娟 张作儒 

机构地区：[1]河北省防疫站

出　　处：《中华流行病学杂志》1994年第3期162-164,共3页Chinese Journal of Epidemiology

摘　　要：对动物侵伤者接种狂犬病疫苗后，用ＥＬＩＳＡ检测血清中抗体，并于一年后对接种者信函调查狂犬病发病情况，借以探讨该检测方法用于血清及流行病学效果的评价，信调应答率８５％，其中抗体阳性组的狂犬病病死率０．２４％（１／４１５），显著低于抗体阴性组的３．１６％（３／９５）（＝Ｐ０．０２２）．抗体阳性组的病死者系狂犬咬伤颌面部、未处理伤口、疫苗６针，潜伏期２８天，血清抗体第２８天Ｐ／Ｎ值为３．２７。fter vaccinating the people bitten by animals against rabies,we have examined their serum antibodies by using ELISA.One year later,we sent a mail to everyone of them inquiring if he had contracted rabies.The response rate was 85%.The case fatality rate of the positive antibodyproup was 0.24%(1/415).The case fatality rateof the negative antiboly group was 3.16(3/95).It showed that there was significant differencein the case fatality rate of rabies between thetwo groups,(P=0.022).The dead person of thepositive antibody group was bitten on his cheekby a rabid dog.He had not cleaned his wound.Hehad received 6 injections of rabies vaccines.Hisincubation period was 28days.The P/N of serumantibody on the 28st day was 3.27.

关 键 词：ELISA 狂犬病 疫苗 血清 流行病学 

分 类 号：R512.990.1[医药卫生—内科学]