新生儿乙肝疫苗第2针接种时间与免疫效果关系研究  

A.Study on Relation Between Effect of HB Vaccination and Time of the Second Injection

作　　者：陈惠峰[1] 郭志宏[1] 顾云忠 张友金 陈桂尧 杨介者[1] 姜霞玲 沈月根 陶志华 王文刚[1] 姚军[1] 钱本立 

机构地区：[1]浙江省卫生防疫站,嘉兴市郊区卫生防疫站,平湖市卫生防疫站

出　　处：《中华流行病学杂志》1994年第6期349-350,共2页Chinese Journal of Epidemiology

摘　　要：新生儿乙肝疫苗免疫接种首针“０”和第３针“６”保持不变，将第２针分为３０、４０、５０、６０天组，于第２针免后和全程免后１个月各采血检测，各组抗－ＨＢｓ阳转率和滴度均无组间差异。不论ＨＢｓＡｇ阴性和ＨＢｓＡｇ阳性母亲组的新生儿抗－ＨＢｓ消长变化均与０、１、６程序结果相似。提示对山区、海岛等受客观条件影响大的地区，新生儿乙肝疫苗第２针接种时间可在３０～６０天完成。hree kinds of hepatitis B vaccinationschedule in neonates were compared. The sche-dule included 0, 40 day,6 month;50 day, 6 month; 0, 60 day,6 month; and was control- led by the 0, 30 day, 6 month schedule. Theresults showed that there was no statisticallysignificant difference among three kinds ofschedule,no matter who were neonates of HBsAg-positive mother or neonates of HBsAg-ne-gative mother,These indicated that in areaswith poor condition,such as mountain, islsad,the second injection of hepatitis B vaccinein neonates may be completed within 30-60days.

关 键 词：疫苗 接种 乙型肝炎 新生儿 免疫效果 

分 类 号：R722.130.1[医药卫生—儿科]