骨代谢生化标志物在氟骨症研究中的应用  

The application of bone metabolism biochemical markers in the study of skeletal fluorosis

作　　者：周建平[1] 袁本利[1] 

机构地区：[1]军事医学科学院毒物药物研究所，北京100850

出　　处：《中国地方病学杂志》2003年第2期186-188,共3页Chinese Jouranl of Endemiology

摘　　要：氟骨症骨转换加速 ,骨代谢异常。用成骨细胞分泌的酶如骨碱性磷酸酶、骨钙素等骨代谢生化标志物评估骨形成 ,用破骨细胞分泌的酶如抗酒石酸酸性磷酸酶及骨吸收中形成的代谢产物如尿羟脯氨酸等生化标志物评估骨吸收。The metabolism of bone is reflected by biochemical markers of bone's resorption, formation and bone turnover. Skeletal fluorosis is characterized by accelerated bone turnover and bone metabolism's disorder. Bone formation markers indicate osteoblast activity: Bone Alkaline Phosphatase which produced by osteoblast is an excellent indicator of bone formation.Osteocalcin, bone Morphogenetic Protein and Procollagen I Carboxyterminal Propeptide are also considerated as some other important markers of osteoblast activity; Markers of resorption represent osteoclast activity: Tartrate Resistant Acid Phosphatase excreted by osteoclast plays an important role in the bone resorption process. Hydroxyproline measurement can also be used as an index of osteoclast's metabolic activity. In conclusion,bone metabolism biochemical markers provide new and potentially important tools for the study of skeletal fluorosis.

关 键 词：骨代谢生化标志物 氟骨症 抗酒石酸酸性磷酸酶 骨碱性磷酸酶 细胞分泌 骨代谢异常 尿羟脯氨酸 代谢产物 骨吸收 骨转换 骨形成 骨钙素 

分 类 号：R599.9[医药卫生—内科学]