小剂量芬太尼对呼吸中枢二氧化碳通气反应的影响  

Effect on veutilatory response to CO_2 produced by small dose or fretanyl.

作　　者：胡晓[1] 谢荣[1] 尹大光[1] 许桂鸿 

机构地区：[1]北京医科大学附属第一医院麻醉科,邮政编码100034

出　　处：《中华麻醉学杂志》1994年第6期433-435,共3页Chinese Journal of Anesthesiology

摘　　要：应用Ｒｅａｄ复呼吸原理，对９例患者进行静注小剂量芬太记后通气对ＣＯ２反应的研究。使用４．７％ＣＯ２， ４８％Ｏ２，余以 Ｎ２平衡的混合气体， ５升的复呼吸囊。以通气对ＣＯ２反应的斜率（　ＶＥ／ＰＥＴＣＯ２）作为呼吸中枢对ＣＯ２反应能力的指标，与麻醉前反应斜率进行自身对照。结果发现静注芬太尼１０ｎｇ／ｋｇ后３小时，尽管患者静息通气可正常，但斜率抑制达５０％，３．５小时和４小时分别抑制达３１％和２０％，注药后４．５小时反应斜率方恢复正常。本文就芬太尼１０ｕｇ／ｋｇ产生通气对ＣＯ２反应抑制的机制以及潜在危害进行了探讨。By Read's rebreathing technique, nine patients were studied the ventilatory responses to carbon dioxide following a small dose of fentanyl intraveneously. Mixed gas consisted of 4. 7%CO2, 48% O2 and balanced by N2 The volume of rebreathing bag was 5 liters. The slope, VE/APFT CO2, of ventilatory response to CO2,was used as the level of ventilatory center response ability to CO2. Slope value before anesthesia was self-contrast. Three hours after a dose of 10 ug/kg fentanyl intraveneously,although the rest ventilation had recovered, the ventilatory slope was depressed to 50%. The slope was depressed to 31% and 20% at 3.5 hours and 4 hours respectively. The mechanism and possible damage of ventilatory depression following a small dose fentanyl intraveneously were discussed.

关 键 词：Read复呼吸技术 芬太尼 呼吸抑制 

分 类 号：R614[医药卫生—麻醉学]