卡托普利在异氟醚控制性降压期间对肾素活性、血管紧张素的影响  

Influence of captopril on plasma renin activity, angiotensin I during isofluraned-induced hypotension.

作　　者：曾邦雄[1] 贺聿国[2] 

机构地区：[1]同济医科大学附属协和医院麻醉科,武汉市邮政编码430022 [2]黄石市第二医院

出　　处：《中华麻醉学杂志》1994年第6期416-418,共3页Chinese Journal of Anesthesiology

摘　　要：２４例控制性降压的择期颅脑手术患者随机分为二组，Ｉ组为单纯异氟醚降压组（ｎ＝１２），Ⅱ组为异氟醚加卡托普利降压组（ｎ＝１２）。两组患者的平均动脉压比降压前降低３０％左右。结果显示，Ｉ组患者血浆血管紧张素（Ａ）Ⅱ浓度较降压前增加２６０％（Ｐ＜０．０１）；Ⅱ组患者血浆ＡⅡ浓度较降压前稍有下降。Ｉ组患者诱导及维持降压的异氟醚呼气末浓度均分别高于Ⅱ组。结论认为，静注卡托普利可减弱降压期间的肾素活性及血管紧张素Ⅱ的浓度，与异氟醚合用于较长时间的控制性降压可能有其优点。The efficacy of intravenous captopril on plasma renin activity (PRA ) and angiotensinⅡ (All ) during isoflurane-induced hypotension were investigated. 24 patients (aged 20-50 years,ASA Ⅰ-Ⅱ )scheduled for elective cerebral surgery were randomly divided into two groups: Group I (isoflurane, n = 12 )and Group J (captopril 0. 15mg/kg plus isoflurane n=12 ). MAP was reduced approximately 30% in all of patients. Angiotensin Ⅱ concentration increased 260% during hypotension in group I, but only a slight reduction in Group Ⅱ. The end-expiratory concentration of isoflurane in Group I were higher than Group I during induced and hypotension period. It is concluded that intravenous captopril can inhibit the increase of PRA and All concentration and less isoflurane required for the deliberated hypotension. Induced-hypotension by the combination of isoflurane with captopril may be advantageous.

关 键 词：控制性降压 异氟醚 卡托普利 肾素活性 

分 类 号：R971.2[医药卫生—药品]