睡眠呼吸暂停综合征合并脑血管病患者的血粘度改变  

Blood Viscosity Changes of Patients with Obstructive Sleeping Apnea Sydrome Combined with Cebrebrovascular Disease

作　　者：陈新华[1] 彭化生 刘心臣[1] 朱明[1] 吴祥振 

机构地区：[1]菏泽医学专科学校,山东菏泽274030 [2]菏泽市第三人民医院 [3]定陶县人民医院

出　　处：《菏泽医学专科学校学报》2001年第2期1-4,共4页Journal of Heze Medical College

摘　　要：目的　分析阻OSAS合并CVD患者的血粘度变化 ,探讨OSAS相关事件与CVD的发病机制。方法　随机抽取OSAS合并CVD患者 6 2例 ,并设立正常对照组 6 0例 ,进行血液流变学检测 ,同时观察血糖、血脂、血浆降钙素基因相关肽、内皮素、等指标。结果　①OSAS合并CVD组PSG监测 ,呼吸紊乱次数、呼吸紊乱指数、平均呼吸暂停时间、最长呼吸暂停时间及平均动脉压均明显高于正常对照组 (P <0 .0 1) ;最低SaO2(% ) ,明显低于正常对照组 (P <0 .0 1)。②血液流变学结果显示 ,OSAS合并CVD患者全血高切粘度、中切粘度、低切粘度、红细胞压积、红细胞聚集指数、红细胞刚性指数明显高于正常对照组 ,差异有显著性 (P <0 .0 1)。OSAS合并CVD组血糖、血浆ET均高于正常对照组 (P <0 .0 1) ;血浆CGRP明显低于正常对照组 (P <0 .0 1)。③OSAS患者脑血管病的发生与呼吸紊乱指数、睡眠低通气、血压增高、红细胞增多、血粘度增加呈正相关。结论　OSAS合并CVD患者血液流变学多项指标明显异常 ,血粘度增高、血脂异常、ET增高是OSAS患者发生CVD的危险因素之一。Objective To analyse blood viscosity changes of patients with OSAS Combined with CVD and study matters concerning OSAS and the pathogeny of CVD. Methods Sixty-two cases of OSAS combined with CVD were selected at random and a normal control group was established, with blood rheology tested and blood sugar, blood-fat, plasma calcitonin gene relative peptide, ET and other indexes observed. Results ① PSG mooitoring OSAS combined with CVD, RDN, AHI, OSAT, LOSAT and average arterial pressure were obviously higher than those in the control group (P<0.01) ; the lowest SaO 2% (LSaO 2%) was obviously lower (P<0.01). ② Blood rheology results showed patients with OSAS combined with CVD had higher whole blood high shear viscosity coefficient, medial shear viscosity coefficient, low shear viscosity coefficient, packed cell volume, sympexis, erythrocyte vigidity index were obviously higher than those in the control group and the differences were characteristic (P<0.01). Blood sugar, blood plasma ET in OSAS combined with CVD group were higher than the control group (P<0.01). ③ There were positive correlation between the cebrebrovascular disease happening among the patients with OSAS and AHI, SH, elevation of blood pressure, erythromatosis, elevation of blood viscosity. Conclusion Several abnormal indexes in blood rheology, elevation of blood viscosity, blood-fat abnorminy and elevation of ET are risk factors that induce CVD among patients with OSAS.

关 键 词：睡眠呼吸暂停综合征 脑血管病 血液流变学 内皮素 降钙素基因相关肽 

分 类 号：R446.112[医药卫生—诊断学] R743[医药卫生—临床医学]