白细胞介素－1受体拮抗剂对小鼠油酸型肺损伤的保护作用  

PROTECTIVE EFFECT OF INTEREUKIN-1 RECEPTOR ANTAGONIST ON OLEIC ACID-INDUCED LUNG INJURY

作　　者：赵鸣武[1] 孙德俊[1] 马大龙[1] 廖松林[1] 狄春辉[1] 刘进[1] 卜捷 

机构地区：[1]北医大第三临床医学院呼吸内科,北京医科大学免疫研究中心,北京医科大学病理教研室

出　　处：《中华内科杂志》1994年第3期158-161,共4页Chinese Journal of Internal Medicine

摘　　要：３６只小鼠分为对照组、油酸肺损伤组及白细胞介素－１受体桔抗剂（ＩＬ－１ｒａ）保护组，每组１２只。油酸由小鼠尾静脉注入，保护组注入上述拮抗剂后再给予油酸。结果表明，保护组肺系数、肺湿／干重比值较低，支气管肺泡灌洗液总蛋白量较少，ＰａＯ＿２较高，肺组织学改变（肺泡水肿、肺泡出血、肺坏死、炎症细胞浸润）明显减轻。认为该拮抗剂对油酸型肺损伤有保护作用，从而为其在成人型呼吸窘迫综合征中的临床应用提供一定依据。hirty-six mice were divided into a control group,lung injury group by oleic acid and protected group with interieukin-1 receptor antagonist(IL一lra).There were 12 mice in each group.Oleic acid was injected into the tail vein ofthe mouse with a dose of 0.2ml/ kg to produee a model ofacute lung injury(ALI).The resuIt indicates that preadministration of IL-lra to the mouse with ALl can decrease the lung index,lung wet-to-dry weight ratio and leakage of protein from pulmonary capillary,elevate PaO_2,and significantly attennate lung histologic injury (alveoli edema,alveoli hemorrhage,lung necrosis,inflammatory cell invasion).It is suggested that IL-lra has protective effect on oleic acid-in-duced lung injury and may be a potential tool for treatment of ARDS。

关 键 词：生物学 白细胞介素1 呼吸窘迫 

分 类 号：R563.805[医药卫生—呼吸系统]