合理应用抗菌药物能减缓细菌耐药性产生  

Antibiotic medicine apply properly for relieving bacterial resistance produce

作　　者：俞慧菊[1] 康金凤[1] 刘瑛[2] 

机构地区：[1]上海第二医科大学附属新华医院儿内科,200092 [2]上海第二医科大学附属新华医院检验科,200092

出　　处：《中国科技信息》2005年第12期136-136,141,共2页China Science and Technology Information

摘　　要：目的:了解临床分离的革兰阳性球菌和革兰阴性杆菌耐药状况,以指导临床合理用药。方法:采用美国生物梅里埃公司的ViteK32全自动微生物/药敏系统进行的菌种鉴定,用微量稀释法(MIC)进行药物敏感试验。结果:金黄色葡萄球菌对阿莫西林、氨苄西林/舒巴坦、头孢唑啉、红霉素、克林霉素、四环素的耐药率分别为83%、82%、81%、90%、85%和86%;凝固酶阴性的葡萄球菌对上述药物的耐药性也在80%以上。大肠埃希菌对阿莫西林、头孢噻吩、培氟沙星和替卡西林的耐药率分别为84%、84%、81%和81%;肺炎克雷伯菌对阿莫西林和替卡西林100%耐药。结论:近年来,临床上可选的抗菌药物越来越多,而细菌产生耐药性迅速增加,使临床治疗带来了很大困难。因此,在临床选用抗菌药物时,必须以《抗菌药物临床应用指导原则》为指导,走出使用抗菌药物误区,做到合理、有效应用抗菌药物,减缓细菌耐药性的产生。Objective: To investigate resistance of clinical isolates of gram-positive cocci and gram-negative, in order to guide put to proper use medicine. Method: Adopt ViteK32 automatic microbe/sensitive system of American biologic Merian company for identifying strains, and use MIC to carry on sensitive test. Results: Staphylococcus aureusr esistanceo ft heser espectively.A moxicillin (83%),A mpicillin/sulbac(82%),C efazolin(81%),E rythromycin(90%),C lindamycin(85%),T etracyclin(86%); coagulase negatives taphylococci resistancea lso have above8 0%.E scherichiac olir esistanceo f theser espectively. Amoxicillin( 84%),C ephalothin(84%), Pefloxacin(81%) andT icarcillin(81%); Klebsiella pneumoniae resist Amoxicillina nd Ticarcillin100%. Conclusion:I nr ecent years,t herea re more andm orea ntibioticsc anb e puti n use inc linic, but microbe produce resistance more and more quickly, so that clinic treatment have many difficulties. So when you choose antibiotics must guide in‘ The principle of clinic antibiotics guide ’, you couldn’t use in wrong way, and antibiotics must be applied properly and efficiently for relieving bacterial resistance produce.

关 键 词：抗菌药物 细菌耐药性 合理应用 减缓 金黄色葡萄球菌 革兰阴性杆菌 药物敏感试验 阿莫西林 肺炎克雷伯菌 微量稀释法 大肠埃希菌 合理用药 菌种鉴定 氨苄西林 头孢唑啉 克林霉素 头孢噻吩 培氟沙星 临床治疗 临床应用 耐药率 

分 类 号：R96[医药卫生—药理学]