不同剂量他巴唑对体内甲状腺过氧化物酶活性的影响  

EFFECT OF DIFFERENT DOSES OF METHIMAZOLE ON HUMAN THYROID PEROXIDASE IN VIVO

作　　者：黄国良[1] 余耀远 张珍[1] 陈大良[1] 林哲章[1] 方克光 陈美爱[1] 

机构地区：[1]福建医学院附属协和医院

出　　处：《中华内分泌代谢杂志》1994年第1期15-16,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：福建省卫生厅青年科学研究基金

摘　　要：应用愈创木酚法对６７例术前服０～４０ｍｇ／ｄ他巴唑（ＭＭＩ）的Ｇｒａｖｅｓ病甲状腺过氧化物酶（ＴＰＯ）活性进行测定。ＭＭＩ为０～１５ｍｇ／ｄ时，随剂量增加ＴＰＯ活性渐降低；当到１５ｍｇ／ｄ时，ＴＰＯ活性基本降至最低，即使再增加剂量，ＴＰＯ活性未再继续降低。ＭＭＩ顿服与分服相同剂量时ＴＰＯ活性相同，对ＴＰＯ抑制作用至少可持续２４小时。因此ＭＭＩＩ５ｍｇ／ｄ是治疗甲亢的合适剂量，每日１次顿服的疗法是合理而有效的。The activities of thyroid peroxidase (TPO)were measured by means of guaiacol assay in 67 patients with Graves disease who had been treated witb 0～40 mg/day methimazole(MMI)preoperatively.With dose of MMI from 0 to 15 mg/day ,TPO activity de-creased with increasing dose,and reached a minimum at the dose of 15 mg/day, but without further decrease even with larger dose than 15 mg/day.There was no difference of TPO activity between patients taking the drug in divided doses and those taking one sin-gle dose of the same amount ,nor between patients taking the final dose 2 hours before thyroid excision and those taking it 26 hours before excision. Our results indicate that MMI 15 mg/day has the greatest inhibitory effect on TOP in vivo ,and inhibitory effectof MMI on TPO may last for 24 hours. The single daily dose of MMI is a reasonable and effective treatment for hyperthyroidism.

关 键 词：他巴唑 甲状腺 过氧化物酶 甲亢 

分 类 号：R581.1[医药卫生—内分泌]