血清妊娠相关蛋白-A在急性冠状动脉综合征时显著升高  

Sigificant increase of serum pregnancy-associated plasma protein A in patients with acute coronary syndrome

作　　者：舒平[1] 刘迪[1] 周惠云[1] 

机构地区：[1]北京大学深圳医院,广东深圳518036

出　　处：《岭南心血管病杂志》2005年第2期91-94,共4页South China Journal of Cardiovascular Diseases

摘　　要：目的探讨血清妊娠相关蛋白鄄A对急性冠状动脉综合征的临床识别和预测作用。方法收集急性冠状动脉综合征患者63例,其中急性心肌梗死29例,不稳定心绞痛34例,稳定性心绞痛38例及正常人20例。采用ELISA方法检测入院时和入院6小时后的血清妊娠相关蛋白鄄A浓度。结果入院时,急性心肌梗死与不稳定心绞痛患者血清妊娠相关蛋白鄄A浓度分别为(20±9)mIU/L和(17±8)mIU/L,明显高于稳定性心绞痛患者(8.4±4.2)mIU/L和正常人(7.2±3.8)mIU/L(P<0.01);入院6小时后与入院时比较,各组间差异无统计学意义。超出10mIU/L病例,急性冠状动脉综合征患者有58例(92%),稳定性心绞痛患者7例(18%),正常人2例(10%),其敏感性和特异性分别为92%和84%。结论急性冠状动脉综合征血清妊娠相关蛋白鄄A明显升高,可以作为诊断急性冠状动脉综合征的辅助新标记物。Objectives To investigate the role of the pregnancy-associated plasma protein A (PAPP-A) on diagnosis and forecast of acute coronary syndrome (ACS). Methods 63 patients with ACS, including 29 of acute myocardial infraction(AMI)and 34 of unstable angina pectoris(UAP)plus 38 of stable angina pectoris(SAP)and 20 of normal controls were enrolled. PAPP-A concentrations in plasma samples at admission and after 6 hours were measured with ELISA. Results PAPP-A levels at admission were significantly higher in patients with AMI(20±9) mIU/L and UAP(17±8) mIU/L than those in patients with SAP (8.4±4.2) mIU/L and normal controls(7.2±3.8) mIU/L,(P<0.001). After 6 hours there were no significant change among the groups. PAPP-A threshold value of 10 mIU/L was identified in the patients with with Acs.According to shis value, there were a sensitivity of 92 percent and a specificity of 84 percent in the patients with ACS. Conclusions The circulating level of PAPP-A is elevated in ACS. PAPP-A is may be a new candidate marker of ACS.

关 键 词：急性冠状动脉综合征 妊娠相关蛋白-A 心肌梗死 心绞痛 

分 类 号：R541.4[医药卫生—心血管疾病]