雄激素致不孕大鼠发病机制及滋肾阴药对其促排卵的作用  

TUDIES ON VALIDITY OF THE ANDROGEN-STERILIZED RAT AND OVULATION-INDUCING EFFECT OF ZI SHEN YIN HERBS

作　　者：张月萍[1] 俞瑾[1] 归绥琪[1] 

机构地区：[1]上海医科大学附属妇产科医院

出　　处：《中华内分泌代谢杂志》1994年第2期98-101,共4页Chinese Journal of Endocrinology and Metabolism

摘　　要：给９日龄ＳＤ雌性大鼠注射丙酸睾丸酮造成雄激素致不孕大鼠（ＡＳＲ），再灌服滋肾阴药后发现，ＡＳＲ卵巢多囊变，无黄体，体外睾酮产量增加，糖耐量下降，血雄激素和胰岛素水平升高，体重增加；滋肾阴药使ＡＳＲ卵巢增大并排卵，体外产生睾酮能力下降，糖耐量上升，血胰岛素和体重下降。结果提示ＡＳＲ的无排卵系高胰岛素血症与卵巢高雄激素血症共同作用所致；滋肾阴药通过降低ＡＳＲ体内胰岛素和雄激素水平而促排卵。Female SD rats of 9 days of age were injected subcutaneously with either testosterone propionate to induce sterility (androgen-sterilized rat, ASR)r vegetable oil(control).They were further subdivided into treated and untreated groups. Beginning from79th day,herbs of Zi Shen Yin or vehicle were fed to both ASR groups(group A+Hand A)and both control groups (group C+H and C).We found that the ovaries of ASR were smaller than those of the other groups with the presence of cystic follicles and ab-sence of corpora lutea. There was more testosterone production in vitro from thecal- interstitial cells as well as a higher blood andro-gen level in ASR. The ASR showed decreased tolerance to glucose with a higher blood insulin level. The body weight of ASR wasgreater than those of the other groups. Treatment with herbs of Zi Shen Yin yielded enlargement of the ovaries with ovulation,while all the other findings were reversed. Our data suggest that hyperinsulinemia and hyperandrogenism are both responsible forthe anovulation of ASR, so ASR may be regarded as the animal model of hyperinsulinemia, hyperandrogenism and anovulation. Herbs of Zi Shen Yin induce ovulation via inhibition on serum levels of insulin and androgen.

关 键 词：雄激素 女性 滋肾阴药 不育症 高胰岛素血症 

分 类 号：R711.6[医药卫生—妇产科学]