自身免疫甲状腺疾病患者淋巴细胞亚群和自身抗体的临床研究  

CLINICAL STUDY ON LYMPHOCYTE SUBPOPULATION AND AUTOANTIBODIES IN THE PATIENTS WITH AUTOIMMUNE THYROID DISEASES

作　　者：王淑芬[1] 阮大宝[1] 钟述猷[1] 张宝泉[1] 邱明才[1] 方佩华[1] 

机构地区：[1]天津医学院附属医院,天津市内分泌研究所

出　　处：《中华内分泌代谢杂志》1994年第3期157-159,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：作者报告１５０例自身免疫甲状腺疾病和２５例亚甲炎患者淋巴细胞亚群、甲状腺自身抗体和甲状腺激素测定结果。ＧＤ和ＨＴ未治组ＣＤ８＋、ＣＤ３＋下降、ＣＤ＋４／ＣＤ＋８比值和ＣＤ＋２０升高（Ｐ均＜０．０１）。ＧＤ未治组ＴＲＡｂ、ＴＭＡ和ＴＧＡ阳性率分别为９０．０％、６１．１％和５７．Ｏ％；ＨＴ未治组为２０．０％、８５．０％和７０．０％。亚甲炎组变化不明显。ＧＤ缓解组以上各指标均转向正常范围。ＧＤ未治组ＣＤ８＋与ＴＲＡｂ呈明显负相关，ＣＤ２０＋与ＴＲＡｂ呈显著正相关。ＣＤ８＋、ＣＤ２０＋与ＴＲＡｂ的检测是判断Ｇｒａｖｅｓ病发病机制及治疗效果和预后的可靠指标。In the present study,lymphocyte ,subpopulation and autoantibodies were investigated in 150 patients with autoimmune thyroiddisease and in 25 patients with subacute thyroiditis. In the untreated groups of Graves disease (GD)and Hashimoto thyroiditis(HT) CD+3 and CD-8 were markedly declined,while the ratio of CD+4/CD+8and CD20+ were significantly elevated(P<0. 01). In theuntreated GD,the positive rates for TRAb,TMA and TGA were 90.0%,61.1%and 57.8%respectively,while they were 20.0%,85.0%and 70.0%re,respectively in the untreated HT. There was no significant change found in the subacute thyroiditis. In the re-mitted group of GD,these indices returned to the normal limits. It was noted in the untreated GD that there was a more significantnegative correlation between TRAb and CD+8 than the positive correlation between TRAb and CD+20. The data suggest that CD-8,CD+20 and TRAb might be the reliable indices for the judgement of the treatment and prognosis of Graves disease.

关 键 词：桥本甲状腺炎 TRAB TMA TGA 甲状腺机能亢进 

分 类 号：R581.103[医药卫生—内分泌]