人类白细胞抗原——氨基酸残基配型在肾移植中的应用  

Application of human leukocyte antigen(HLA)-amino acid residue matching in kidney transplantion

作　　者：周辉[1] 谢晋良[2] 龚志军[1] 梁婷[1] 唐发清[1] 唐银[1] 

机构地区：[1]中南大学湘雅医院检验科,湖南长沙410008 [2]中南大学湘雅医院器官移植中心,湖南长沙410008

出　　处：《中国医学工程》2005年第3期263-264,共2页China Medical Engineering

摘　　要：目的探讨人类白细胞抗原(HLA)—氨基酸残基配型在肾移植中的临床应用价值。方法应用HLA氨基酸残基配型(ResM)标准及传统的六抗原配型标准(AgM)。分析在尸肾移植中HLA——氨基酸残基配型对肾移植结果的影响。结果采用ResM标准可大幅度提高相配几率,0、1mm组受者由1.8%提高到42.9%;2mm组受者由1.8%提高到41.1%。结论新的ResM标准具有实用性与可行性,可大幅度提高移植供受者的相配几率,适合于肾移植的临床应用。[Objective] To study the clinic application of HLA-amino acid residue matching in kidney transplantation. [Method] HLA-amino acid residue matching (ResM) and HLA six-antigen match program (AgM) were used to analyse the influence of HLA-amino acid residue of cadaver kidney transplantation. [Result] The rate of Res-matched transplants increased greatly. The rate of 0~1 mm recipients increased from 1.8% to 42.9%, and that of 2 mm transplants from 1.8% to 41.1%. [Conclusion] New ResM has been proved to be suitable and feasible, and can greatly enhance the rate of transplants, which is suitable for clinical application in kidney transplantation.

关 键 词：肾移植 氨基酸残基配型 人类白细胞抗原 HLA 抗原分型 

分 类 号：R699.2[医药卫生—泌尿科学]