用基因重组丙型肝炎病毒抗原C11和C7对丙型肝炎进行分析  

AN ANALYSIS OF HCV INFECTION BY USING BECOMBINATE HCV ANTIGEN C11 AND C7

作　　者：陈乃玲[1] 程明[1] 贾克明[1] 于春[1] 程达荣 顾芳[1] 纪颖[1] 邓燕林[1] 赵莉[1] 杨俊英[1] 鲍秋莉 

机构地区：[1]中国人民解放军肝病研究所,卫生部北京生物制品研究所,中国人民解放军海军总医院

出　　处：《中华内科杂志》1994年第1期31-32,共2页Chinese Journal of Internal Medicine

摘　　要：使用基因重组丙型肝炎病毒（ＨＣＶ）基因核心区所表达的抗原Ｃ１１及非结构区ＮＳ３区所表达的抗原Ｃ７，对北京地区慢性病毒性肝炎、肝硬化、原发性肝瘤４４２例进行了血清丙型肝炎病毒抗体（抗ＨＣＶ）检测。初步看出本地区乙型肝炎更多于丙型肝炎。肝硬变、原发性肝癌在病因学上与乙、丙型肝炎重叠感染的关系比单独乙型或单独丙型肝炎感染的关系更为密切。提示这些患者中乙型及丙型肝炎病毒之间有相互作用的可能性。he recombinate protein C11 derived from the C region of HCV genome and C7 derived from the nonstructural region NS3 of the HCV genome were used in ELISA to study 442 cases of liver diseases,including chronic hepatitis,cirrhosis and hepatocellular carcinoma in Beijng District.It was found that HBV infection was more prevelent than HCV infection in this district.Both liver cirrhosis and hepatocellular carcinoma were more related to the superinfection of HBV and HCV rather than HBV infection alone or HCV infection alone. It is suggested that there may be some interaction be-tween the HBV and HCV to worsen the prognosis of these patients.

关 键 词：丙型肝炎病毒 重组 基因 抗原 

分 类 号：R512.630.3[医药卫生—内科学]