双(α-呋喃甲酸)氧钒对糖尿病大鼠血糖的调节作用  

Modulation effect of bis (α-furancarboxylato)oxovanadium (IV) on blood glucose in diabetic rats

作　　者：高丽辉[1] 谢明进[2] 李玲1 刘伟平[2] 李艳蓉[1] 陈植和[1] 

机构地区：[1]昆明医学院省天然药物药理重点实验室,云南昆明650031 [2]昆明贵金属研究所,云南昆明650221

出　　处：《药学学报》2005年第6期496-500,共5页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目 (30260118 ); 云南省自然科学基金资助项目(2002C0019R).

摘　　要：目的　研究双(α- 呋喃甲酸)氧钒(VO FA)对正常大鼠及链脲佐霉素(STZ)性糖尿病大鼠的降糖作用。方法　以STZ诱导大鼠糖尿病模型。观察VO FA灌胃给药后,对血糖、糖化血红蛋白、糖原和血清胰岛素等的影响。结果　VO FAig两周后,剂量依赖性地降低STZ性糖尿病动物的血糖水平,但对正常动物的血糖无影响。VO FA56 8mg·kg-1可降低正常动物血清胰岛素水平,加倍剂量尚能降低STZ性糖尿病大鼠的血清胰岛素水平。此外,VO FA能降低糖尿病大鼠的糖化血红蛋白,明显改善糖耐量,增加肌糖原和肝糖原的含量,并呈现出量效关系,但对正常动物则没有影响。结论　VO FA可以改善糖尿病动物的糖代谢,而不影响正常动物的血糖水平。Aim To study the hypoglycemic effect of bis (α-furancarboxylato) oxovanadium (IV) (VO-FA) in normal rats and streptozotocin (STZ)-diabetic rats. Methods Rats were injected intraperitoneally STZ 50 mg·kg^-1 to induce diabetes. Blood glucose, glycohemoglobin, glycogen and serum insulin were observed after administering intragastrically VO-FA for four weeks. Results After 2 weeks administration, VO-FA reduced the blood glucose in STZ-rats (P<0.01) dose-dependently, and up to 4 weeks the blood glucose was normalized (below 11.1 mmol·L^-1) in some of STZ-rats, whereas did not decrease in normal rats. After administration of VO-FA at the dosage of 56.8 and 113.6 mg·kg^-1, the serum insulin levels were lowered in normal rats and STZ-rats, respectively. Moreover, VO-FA reduced glycohemoglobin, improved the glucose tolerance, and increased the liver glycogen and muscle glycogen contents in STZ-rats in a dose-dependent manner (~P<0.05, P<0.01), but not in normal rats. Conclusion VO-FA could improve the glycometabolism in STZ-rats, but not in normal rats.

关 键 词：双(Α-呋喃甲酸)氧钒 糖尿病大鼠 血糖 胰岛素 

分 类 号：R965[医药卫生—药理学] R977.15[医药卫生—药学]