盐酸苯环壬酯对最大电休克发作及戊四氮惊厥模型的抗惊作用  

Anticonvulsant effect of phencynonate hydrochloride on maximal electroshock seizure and the metrazol seizure threshold test in mice

作　　者：王永安[1] 周文霞[1] 刘艳芹[1] 郑建全[1] 刘克良[1] 阮金秀[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850

出　　处：《药学学报》2005年第6期501-506,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金重点项目 ( 203900508 );国家自然科学基金资助项目(30400551).

摘　　要：目的　评价盐酸苯环壬酯抗癫痫疗效,探讨其抗癫痫作用机制。方法　建立不同癫痫发作模型,评价盐酸苯环壬酯等药物抗癫痫疗效;观察盐酸苯环壬酯等药物对致死剂量NMDA中毒小鼠、NMDA诱导的原代培养大鼠海马神经细胞损伤及NMDA诱发电流的影响。结果　盐酸苯环壬酯在不同癫痫发作模型上均具明显抗惊作用;并可显著对抗致死剂量NMDA中毒,浓度依赖性抑制NMDA诱导原代培养大鼠海马神经细胞损伤及NMDA诱发电流。结论　盐酸苯环壬酯在经典癫痫模型上均具显著抗惊作用,其作用机制可能与其对NMDA受体的拮抗作用有关。Aim To test the antiepileptic effect of phencynonate hydrochloride and investigate its antiepileptic mechanism. Methods Through establishment of different epilepsy models, antiepileptic effects of phencynonate hydrochloride and other drugs were examined. Besides, the effect of phencynonate hydrochloride and other compounds against NMDA-induced lethality in mice, NMDA-induced injury in rat primary hippocampal neuronal cultures and NMDA-induced current were also observed. Results Phencynonate hydrochloride produced a significant anticonvulsant effect on different epilepsy models. Furthermore, phencynonate hydrochloride also exerted its obvious protection against the lethal effects of NMDA in mice, antagonized the NMDA-induced injury in rat primary hippocampal neuronal cultures and blocked NMDA-induced current in a dose-dependent manner. Conclusion Phencynonate hydrochloride had a notable anticonvulsant effect on typical epilepsy models, its antiepileptic mechanism might relate to its antagonism against NMDA receptor.

关 键 词：盐酸苯环壬酯 癫痫 N-甲基-D-天冬氨酸 

分 类 号：R965[医药卫生—药理学] R971.6[医药卫生—药学]