风湿性心脏瓣膜病慢性心房颤动患者白细胞介素-1β和肿瘤坏死因子-α蛋白表达的研究  

Changes of interleukin-1beta and tumor necrosis factor-alpha of right atrial appendages in patients with rheumatic valvular disease complicated with chronic atrial fibrillation

作　　者：王长华[1] 胡大一[1] 汤楚中[1] 吴明营[1] 梅运清[1] 赵建刚[1] 齐弘伟[1] 

机构地区：[1]首都医科大学附属北京同仁医院心血管中心,100730

出　　处：《中华心血管病杂志》2005年第6期522-525,共4页Chinese Journal of Cardiology

摘　　要：目的观察风湿性心脏瓣膜病慢性心房颤动(房颤)患者右心耳白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)蛋白表达的改变。方法将48例接受心脏外科手术的风湿性瓣膜病患者于术中获取的右心耳分为两组,其中窦性心律组27例,慢性房颤组21例,采用病理学检查评价心房组织炎症细胞浸润和纤维化,采用免疫组织化学检查评价IL-1β和TNF-α蛋白表达的变化。结果慢性房颤患者心房组织有显著的纤维化,而且其心房肌细胞IL-1β和TNF-α的表达强度也显著大于窦性心律组。结论风湿性心脏瓣膜病慢性房颤患者心房组织IL-1β和TNF-α蛋白的表达显著增加,炎症反应可能是风湿性心脏瓣膜病慢性房颤患者房颤发生和维持的机制之一。Objective To investigate whether atrial expression of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) of right atrial appendages are altered in patients with rheumatic valvular disease during chronic atrial fibrillation.Methods A total of 48 patients with rheumatic heart disease were included. 27 patients had no history of atrial fibrillation, 21 patients had atrial fibrillation. Atrial tissue was obtained from the right atrial appendage during open heart surgery. The protein expression of IL-1β and TNF-α was detected by immunohistochemistry method. The fibrosis of right atrial appendage was detected by Masson staining.Results The fibrosis of right atrial appendage was significantly increased in patients with chronic atrial fibrillation. The protein expression of IL-1β and TNF-α were significantly increased in patients with chronic atrial fibrillation.Conclusions The protein expression of IL-1β and TNF-α were significantly increased in patients with rheumatic valvular disease during chronic atrial fibrillation. Inflammation may be one of the mechanisms for the development and persistence of atrial fibrillation.

关 键 词：风湿性心脏瓣膜病 慢性心房颤动 白细胞介素-1Β 肿瘤坏死因子-Α 蛋白表达 

分 类 号：R541.2[医药卫生—心血管疾病] R541.75[医药卫生—内科学]