微量白蛋白尿与血浆高敏C反应蛋白的关系  

The relationship between microalbuminuria and plasma high sensitivity C reactive protein

作　　者：严江涛[1] 叶辉[1] 汪道文[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院内科,武汉430030

出　　处：《中华心血管病杂志》2005年第6期534-535,共2页Chinese Journal of Cardiology

基　　金：国家重点基础研究发展规划(973)项目资助(G2000056901)

摘　　要：目的探讨微量白蛋白尿(MA)与血浆高敏C反应蛋白(hsCRP)水平的关系。方法采用ELISA的方法分别对746名国人血浆hsCRP和尿微量白蛋白水平进行检测,并进行统计学分析。结果MA组血浆hsCRP水平显著高于对照组[(2.23±3.35)mg/L比(1.68±2.58)mg/L,P<0.05];血浆hsCRP水平超过0.77mg/L时,MA的发生率明显增加(P<0.05);MA的发生与hsCRP水平成正相关(OR=1.153,P<0.05)。结论hsCRP水平升高可能参与MA的发生,提示炎症反应可能具有促进内皮功能损害的作用。Objective To investigate the relationship between microalbminuria (MA) and plasma high sensitivity C reactive protein (hsCRP).Method The plasma hsCRP level and urine albumin level of 746 Chinese people were detected with ELISA and analyzed, respectively.Result The hsCRP level of MA group increased significantly compared with the control group(2.23±3.35 mg/L vs 1.68±2.58 mg/L, P <0.05), the incidence of MA increased significantly when the plasma hsCRP level was beyond 0.77 mg/L ( P <0.05); logistic analysis showed that the occurrence of MA was associated with the plasma hsCRP level( OR =1.153, P <0.05).Conclusion Increased plasma hsCRP was probably involved in the occurrence of MA, suggesting that inflammation may deteriorate endothelial dysfunction.

关 键 词：微量白蛋白尿 血浆 高敏C反应蛋白 心血管疾病 血管炎症 动脉粥样硬化 

分 类 号：R446.6[医药卫生—诊断学]