检测原发性肝癌血清可溶性细胞间黏附分子-1的临床价值  

Clinical value of detecting the levels of serum intercellular adehesion molecule-1in hepatocellular carcinoma

作　　者：简志祥[1] 孙建[1] 侯宝华[1] 区金锐[1] 

机构地区：[1]广东省人民医院普外科,广州市510080

出　　处：《实用医学杂志》2005年第12期1266-1268,共3页The Journal of Practical Medicine

基　　金：广东省人民医院科研基金项目(Y02059)

摘　　要：目的:探讨检测原发性肝癌(HCC)血清可溶性细胞间黏附分子-1(sICAM-1)水平的临床价值。方法:采用ELISA法同期检测了53例HCC患者血清sICAM-1及AFP的含量,并与肝脏良性肿瘤、慢性肝炎肝硬化及健康志愿者相比较。结果:HCC患者血清sICAM-1含量均值为(1382.5±752.3)ng/mL,显著高于各对照组(P<0.01);而肝脏良性肿瘤、肝炎肝硬化及健康志愿者之间差异无显著性(P>0.05);HCC患者血清sICAM-1含量与肿瘤大小、有无包膜及转移状态有关(P<0.05),而与肿瘤组织学分级、血清AFP水平无关(P>0.05)。结论:sICAM-1在HCC发生发展过程中起重要作用,检测血清sICAM-1对于HCC的诊断有重要价值,并有助于判断HCC患者肿瘤侵袭转移状态及病情监测。Objective To evaluate th e clinical value of detecting the levels of serum intercellular adehesion molecu le-1in hepatocellular carcinoma.Methods The serum levels of sICAM-1in 53 pati ents with HCC and 30controls were measured by using ELISA,and com pared .Results The serum levels of sICAM-1in HCC gro up were significantly higher t han those in control group(P<0.01).And there were higher levels of sICA M-1in patients with large tumor(≥5cm or tumor nodules≥3)or invasive tumo r(showing invasion to veins)compared with those with small tumor(<5cm or tu mor nodules <3)or non-invasive tumor(P<0.05).The serum levels of sIC AM-1in HCC patients showed no relationship with tumor histologic al grade and serum AFP(P>0.05).Conclusions These data showed a correlation between t he sICAM-1and the potentia l of invasion and metastasis in HCC,a nd serum sIC AM-1level is an sensitiv e marker for tumor progression and prognosis of the p atients.[

关 键 词：血清可溶性细胞间黏附分子-1 原发性肝癌 临床价值 血清SICAM-1 检测 肝脏良性肿瘤 健康志愿者 肝炎肝硬化 ELISA法 转移状态 HCC 组织学分级 肿瘤大小 发生发展 病情监测 肿瘤侵袭 患者 含量 AFP 对照组 显著性 P水平 

分 类 号：R735.7[医药卫生—肿瘤]