大剂量阿托品治疗急性有机磷农药中毒M受体上调的实验研究  

EXPERIMENTAL RESEARCH ON TREATMENT OF ACUTE ORGANOPHOSPHORUS INSECTISIDES POISONING WITH HIGH-DOSE ATROINE RESULTING IN UPREGULATION OF MUSCARINIC RECEPTPR

作　　者：司福中[1] 王德新[1] 杨广泉[1] 欧阳明刚[1] 陈玉萍[1] 洪尚游[1] 武宗义[1] 郝清华[1] 

机构地区：[1]山东省滕州市中心人民医院

出　　处：《中华内科杂志》1994年第9期583-586,共4页Chinese Journal of Internal Medicine

摘　　要：急性有机磷农药中毒（ＡＯｌＰ）是临床常见急症，目前多采用大剂量阿托品治疗（ＨＤＡＴ）。本研究旨在验证ＡＯｌＰ时ＨＤＡＴ会导致Ｍ受体（Ｍ－Ｒ）上调。取同批同种体重相当的雄性小鼠随机分为三组，用敌敌畏４０ｍｇ·ｋｇ￣－１染毒，Ａ组用ＨＤＡＴ７天，Ｂ组用ＨＤＡＴ３６小时。Ｃ组用小剂量阿托品治疗３６小时，然后用放射性核素测定各组脑和心房的Ｍ－Ｒ的Ｂｍａ×值（ｆｍｏｌ·ｍｇｐｒｏｔｅｉｎ￣－１）。结果Ａ、Ｂ两组比对照组显著增加（Ｐ＜０．０１），Ｃ组无明显差别（Ｐ＞０．０５），表明ＨＤＡＴ引起了机体生理状态的改变。这种改变可能与中毒反跳和阿托品依赖的产生机理有关。cute organophosphorus insectisides poisoning(AOlP)is a common medical emergency.There is.at present,a tendency to use high-dose atropine treatment (HDAT). This study aims to test if,during AOIP, HDAT would cause upregulation of muscarinic receptor(M-R). Male mice of the same batch and strain were raised,randomly divided into 3 groups and orally fed with DDVP of the samc dose.HDAT for 7 days was given to group A,HDAT for 36 hours was given to group B and low-dose atropine treatment for 36 hours was given to group C. Then radionuclide assay was employed to meas-ure the M-R in the brain and atrium ofthe mice in each group. The results were that,compared with a control group, the Bmax values(fmol·mg protein￣-1)of M-R in groups A and B were increased significantly(P< 0.01),while that in group C showed no evident change(P> 0.05) These results indi-cate that H DAT leads to some physiological change in the body, which may be responsible for the de-velopment of poisoning rebound and atropi ne dependence

关 键 词：杀虫剂 阿托品 农药中毒 受体 

分 类 号：R595.405[医药卫生—内科学]