银屑病家系与HLA致病单倍型研究  

Study on HLA Susceptible Haplotype of Psoriasis in 23 Families

作　　者：李世泰[1] 安家滨 徐林敏 

机构地区：[1]中国医学科学院北京协和医院,邮政编码100730 [2]北京市儿科研究所白细胞室

出　　处：《中华皮肤科杂志》1994年第5期281-283,共3页Chinese Journal of Dermatology

摘　　要：报告２３个多发银屑病家系及５９例无亲缘关系银屑病患者ＨＬＡ抗原频率分布。其增高的抗原为ＨＬＡ－Ａ１９，Ｂ１３、ＤＲ７（Ｐｃ＜０．００１），降低的抗原为ＨＬＡ－Ｃ７，ＤＱ１，（Ｐｃ＜０．００１），提示具有（Ｃｗ（Ｃ７）者对银屑病的发生具有某种防护作用。２３个家系中，健康同胞５５例，其中２０例与患病同胞有一条或两条单倍型相同，经６～８年观察，４例已发病；另３５例无相同单倍型者，未发病。提示对银屑病家系检测ＨＬＡ单倍型有助于对具有致病单倍型的健康同胞的临床监测。This article reports the results of HLA antigen distribution in 23 families with multiple affected siblings alld 59 unrelated patients with psoriasis vulgaris. The frequency of HLA - A19, B13 and DR7 was significantly higher(Pc 0. 001) than that of controls. It seems that the lower frequency of C7 and DQ1 is resistant to the development of psoriasis. Fifty -five health siblings in 23 families were observed for six to eight years. 20 out of 55 siblings had one or two same HLA haplotypes. Among the 20 persons, 4 siblings had psoriasis vulgaris,35 out of 55 siblings had no similar HLA haplotype and have not affected with psoriasis vulgaris up to now. It shows that HLA haplotype determination is helpful for the clinical surveillance of their healthy sibling with susceptible haplotype.

关 键 词：银屑病 人白细胞抗原 单倍型 

分 类 号：R758.630.3[医药卫生—皮肤病学与性病学]