人胎垂体组织培养及移植治疗席汉氏病  

Study on pituitary tissue culture and transplantation in 5 patients with Sheehan's Syndrome

作　　者：刘宗印[1] 黄丽华[1] 孙金风[1] 耿秀兰[1] 任东俊[1] 

机构地区：[1]济南市中心医院,济南市医学科学研究所

出　　处：《中华器官移植杂志》1994年第3期105-106,共2页Chinese Journal of Organ Transplantation

摘　　要：将水囊引产死胎的垂体组织进行体外培养后，其细胞形态正常，用放射免疫法测得培养２～２１天的培养液中均含有生长激素（ＧＨ）、催乳激素（ＰＲＬ）、黄体生成素（ＬＨ）、卵泡刺激素（ＦＳＨ）、促甲状腺激素（ＴＳＨ）等５种垂体激素。用培养５～１２天的垂体组织给５例席汉氏病患者进行三角肌内注射移植，患者的症状改善，血中垂体激素（ＰＲＬ、ＬＨ、ＦＳＨ及ＴＳＨ）及靶腺激素（Ｔ３、Ｔ４、Ｅ２）水平均有不同程度的提高，说明胎垂体组织经体外培养可以存活，并具有分泌功能。近期观察垂体移植对席汉氏病有一定疗效。This study showed that fetal pituitary tissue cultured in vitro had normal morphological structure. The RIA assay showed that there were GH, LH, TSH, PRL and FSH in cultured solution. Fetal pituitary tissue cultured for 5￣21 days was successfully transplanted to 5 patients with Sheehan’s Syndrome. After the transplantation, the main symptoms of the patients were improved, and the serum levels of T3 , T4 , TSH , E2 , LH , FSH and cortisone increased. This study showed that transplantation of cultured fetal pituitary tissue might reconstitute partial pituitary function, and had recent therapeutic effect on Sheehan's Syndrome.

关 键 词：胎垂体 培养 移植 席汉氏病 

分 类 号：R651.13[医药卫生—外科学]