HLA－A、B抗原与前次相同但与受者不相合对再次移植肾功能的影响  

Significance of repeated HLA-A, B mismatches in the patients of renal retransplantation

作　　者：王从义[1] 程敦秀[1] 曹凡军 黄三香 夏穗生[1] 

机构地区：[1]同济医科大学器官移植研究所

出　　处：《中华器官移植杂志》1994年第3期121-122,共2页Chinese Journal of Organ Transplantation

摘　　要：总结２０例再次肾移植患者的存活情况，探讨有重复的Ⅰ类抗原且与受者不相合对再次移植肾功能的影响。结果显示，再次移植与前次供肾至少有一个相同的ＨＬＡ－Ａ、Ｂ抗原且与受者不相合对移植物的短期存活率、１年及２年存活率均无明显影响（Ｐ＞０．０５）。因而认为再次移植受者在选择二次供肾时，不必避免有重复的Ⅰ类抗原且与其不相合的供肾。这一结果可增加再次移植受者特别是高致敏者选择供肾的机会。In order to elucidate the effect of repeated class Ⅰ mismatches on retransplant renal grafts, 20 cases of retransplants in a total of 226 renal transplantations were evaluated. Tissue matching was standard NIH technique. Carbonyl iron powder and nylon wool techniques were used in isolation of B lymphocytes for class Ⅱtyping.The results indicated that it had no significant effect on retransplant's early, 1-year and 2-year survival (P> 0. 05) in the case of the second kidney shared at least one mismatched HLA-A and B antigen with the first donor.It suggested that retransplantation could be performed in the presence of repeated class Ⅰ mismatches, and that it might increase the chance of retransplantation, especially in highly sensitized patients to select a negative kidney.

关 键 词：白细胞抗原 肾移植 存活 

分 类 号：R699.2[医药卫生—泌尿科学]