固定化猪胰腺细胞移植治疗糖尿病小鼠的实验观察  

Experimental Treatment of Diabetes with Encapsulated Pancreatic Islets in Mice

作　　者：唐天华[1] 姜枫勤[1] 王美岭[1] 张胜兰[1] 刘金生[1] 

机构地区：[1]济南山东省医学科学院基础医学研究所,中国人民解放军济南军区总医院内分泌科

出　　处：《中华器官移植杂志》1994年第4期171-172,共2页Chinese Journal of Organ Transplantation

摘　　要：用链脲霉素制备合格的糖尿病模型小鼠２４只，随机分为３组：对照１组为生理盐水组，对照２组为植入猪胰腺细胞组，治疗组为植入用免疫隔离膜包裹的猪胰腺细胞组。植入量均为１００ｍｇ。结果表明：治疗组小鼠在完全停用胰岛素的情况下，于第７天左右血糖水平可降至８．１１±３．０６ｍｍｏｌ／Ｌ并能维持２～４．５个月，与对照１、２组１９．６７±２．４５ｍｍｏｌ／Ｌ和１３。４４±２，５７ｍｍｏｌ／Ｌ相比均有显著差异（Ｐ＜０．０１；Ｐ＜０．０５）。可见免疫隔离膜具有良好的生物膜性，可以有效地避免宿主抗移植物的排斥反应，使猪胰腺细胞在小鼠体内仍具有生物功能。The diabetic mice induced by streptozotocin were separated into three groups: Nomal saline (NS) injection group, unencapsulated pancreatic islets transplantation group and encapsulated islets transplantation group. The results showed that allmice in the first group died in 14 days, and that the second and the third groupsurvived much longer. On the 7th day the mean leves of the blood glucose in the first, second and third group were 354. 429±44. 109 mg/dl. 242. 125±46.268mg/dl and 146. 125±55.13mg/dl respectively.The results suggested that microencapsulated islets had high biological activity and that microencapsulation could prevent islets from rejection.

关 键 词：免疫隔离膜 胰腺细胞 糖尿病 血糖 

分 类 号：R587.105[医药卫生—内分泌]