超氧化物歧化酶和脂质过氧化物丙二醛在犬肾移植中的变化分析  

Alterations of SOD activity and MDA Content in Canine Blood During Kidney Transplantation

作　　者：左利群[1] 张肖红[1] 谷艳丽 

机构地区：[1]武汉同济医科大学器官移植研究所

出　　处：《中华器官移植杂志》1994年第4期164-165,共2页Chinese Journal of Organ Transplantation

摘　　要：本文测定了２１只犬在正常、肾移植前和肾移植恢复血流后１小时，血中超氧化物歧化酶（ＳＯＤ）活性和脂质过氧化物丙二醛（ＭＤＡ）含量的变化。结果发现：在肾移植前和肾移植恢复血流后１小时与正常时相比，血中ＳＯＤ活性明显下降（Ｐ＜０．００１），同时血中ＭＤＡ含量显著升高（Ｐ＜０．００１），尤以移植后恢复血流１小时为甚。提示了在肾移植过程中，加入一定的自由基清除剂等，对术后恢复将有重要的作用，而在肾保存中移植后加入抗氧化剂至关重要。Blood samples from 21 dogs were collected before,after kidney procurement and 1 hour after kidney transplantation. SOD activity and MDA content in the blood were detected. The results showed that SOD activities both after kidney procurement and 1 hour after kidney transplantation were significantly lower than those before kidney procurement (P< 0. 001). While the MDA concen-trations were increased after procurement, and were especially high 1 hour after kidney transplantation (P<0. 001). It has suggested that the anti-free-radocals agents might have beneficial effects on the recovery of graft function.

关 键 词：肾移植 超氧物歧化酶 丙二醛 过氧化脂质 MDA 

分 类 号：R699.2[医药卫生—泌尿科学]