环(L-亮-L-组)二肽催化不对称氰醇化反应研究  

Cyanohydrintion Catalyzed by Chiral Cyclodipeptide Cyclo (L-Leu-L-His)

作　　者：彭国丽[1] 刘廷凤[2] 

机构地区：[1]南京金陵科技学院,江苏南京210038 [2]南京工业大学,江苏南京210009

出　　处：《江苏化工》2005年第3期40-41,45,共3页Jiangsu Chemical Industry

摘　　要：以合成的光学活性环(L-亮-L-组)二肽,在0^-10℃的混合溶剂中、碱性条件下催化氰醇化反应得到光学活性氰醇(S)-α-氰基3-苯氧基苯乙醇,收率85%,对映体过剩值37%。As an important catalysts for asymmertrical cyanohydrination, cyclo(L-Leu-L-His) was applied to catalyze cyanohydrintion. With ether/toluene as solvent, the pH value higher than 7.0, and the reaction temperature at 0^-10℃, m-phenyloxybenzaldehyde has been converted to (S)-alpha-cyano-3-phenoxy benzyl alcohol, under the catalysis of cyclo(L-Leu-L-His), giving a 85% yield and 37% enantiomeric excess (e.e.).

关 键 词：手性环二肽 环(L-亮-L-组) 合成 氰醇化 

分 类 号：O621.34[理学—有机化学]