慢性肾功能不全与内源性洋地黄物质  

THE CORRELATION BETWEEN ENDOGENOUS DIGITALIS-LIKE SUBSTANCE AND CHRONIC RENAL INSUFFICIENCY

作　　者：熊旭明[1] 尹培达[2] 

机构地区：[1]广州医学院二附院内科,510260 [2]中山医科大学肾脏研究所,510080

出　　处：《中华肾脏病杂志》1994年第2期80-83,共4页Chinese Journal of Nephrology

摘　　要：我们用放免法(RIA)测定了47例慢性肾功能不全、35例维持血透、25例肾移植患者血中内源性洋地黄物质(EDLS)水平。结果显示:随着肾功能的降低,血中EDLS水平升高。EDLS与内生肌酐清除率呈负相关,r=-0.638,p<0.001。认为EDLS浓度升高产生对钠-钾-三磷酸腺苷酶(Na-K-ATP酶)的抑制在慢性肾功能不全发病过程中具有重要意义,血透可使EDLS水平降低。当移植肾功能正常后,EDLS水平降至正常。EDLS与肾性高血压的关系尚不明确。To study the relationship between endog-enous digitalis-like substance (EDLS) and ch-ronic renal insuffieiency(CRI), using radioimmu-noassay (RIA)with digoxin kit, we measured serum level of EDLS in patients with CRI, patients on hemodialysis (HD) and renal tra-nsplant patients. The results suggest that serum level of EDLS is closely related with renal function. When renal function goes down, the level of EDLS increases. This suggest that EDLS may be involved in pathogensis of CRI. HD can decrease serum level of EDLS. When the graft is functioning, the serum level of EDLS is similar to that in haalthy controls. The cor-relation between ELLS and renal hypertension is not clear.

关 键 词：洋地黄 肾功能不全 酶 

分 类 号：R692.5[医药卫生—泌尿科学]