急性丙型肝炎患者免疫状况的研究  

The Immune State in Patients with Acute Hepatitis C

作　　者：张春英[1] 王豪[1] 殷珊 孙焱[1] 常锦红[1] 冯百芳[1] 

机构地区：[1]北京医科大学肝病研究所

出　　处：《中华实验和临床病毒学杂志》1994年第1期35-37,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：用间接免疫荧光法、酶联免疫吸附试验（ＥＬＩＳＡ）及ＬＤＨ释法，对１６例急性输血后丙型肝炎（抗－ＨＣＶ、ＨＣＶ－ＲＮＡ均阳性）患者，分别进行外周血单个核细胞（ＰＢＭＣ）的Ｔ细胞亚群计数、Ｔ４／Ｔ８比值、Ｔａｃ受体的检测及血清可溶性白细胞介素２受体（ｓＩＬ－２Ｒ）ＮＫ细胞活性的测定。并与正常人组比较，经ｔ检验发现，急性丙型肝炎患者的Ｔ４亚群所占百分比、Ｔ４／Ｔ８比值及ＰＢＭＣＴａｃ受体表达均明显低于正常人组（Ｐ＜０．０５），而ＮＫ细胞活性、血清ｓＩＬ－２Ｒ明显高于正常人组（Ｐ＜０．０５）。患者的这些免疫状态改变，可能对其发病机理的研究有一定意义。Sixteen patients with acute hepatitis C were detected for the percentage of T subpopulation, the ratio of T4 and T8, the expression of IL-2R in PBMC (Tac recepteor), the soluble IL-2R (sIL-2R) in serum, and the activity of NK cells. Comparing of normal group with patients, the results showed that the percentage of T4/T8 ratio and the expression of Tac reduced significantly (P<0.05). But the activity of NK cells and the sIL-2R level in serum increased significantly (P<0.05).These immune changes in patients with acute hepatitis C may be of help for research on pathogenesies of acute hepatitis C.

关 键 词：急性 丙型肝炎 免疫学 

分 类 号：R512.630.3[医药卫生—内科学]