轮状病毒胃肠炎患儿对轮状病毒诱生干扰素的反应  

Response to Interferon Induced by Rotavirus in Children with Rotavirus Gastroenteritis

作　　者：姚英民[1] 王兆民[1] 谢孟坤[1] 黄志光[1] 

机构地区：[1]广州第一军医大学南方医院儿科

出　　处：《中华实验和临床病毒学杂志》1994年第2期143-145,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：动态观察了轮状病毒胃肠炎患儿外周血单个核细胞在轮状病毒（ＲＶ）诱导下干扰素（ＩＦＮ）的反应性，研究了ＩＦＮ与白细胞介素２（ＩＬ－２）之间的关系。结果显示，急性期患儿８０％可诱生出ＩＦＮ，恢复期仅２５％有此反应，而健康对照组小儿则无反应；在培养上清中，可同时检出ＩＦＮ和ＩＬ－２，但两者分泌高峰时相不同步，ＩＦＮ在急性期，而ＩＬ－２在恢复期。上述结果提示，ＲＶ感染可激活机体的ＩＦＮ系统，在抗ＲＶ免疫中ＩＦＮ可能是早期最重要的免疫保护因子。The response to interferon (IFN) secreted by peripheral blood mononuclear cell (PBMNC) induced by rotavirus (RV) in vitro in chidren with RV gastroenteritis and the relation between IFN and interleukin-2 (IL-2) were observed dynamically.The results showed that: The PBMNC of 80% sick children could secrete IFN in acute stage,only 25% could secrete it in the recovery stage, but the healthy children in control group had no response. The IFN and IL-2 could be elicited in the supernatant of culture at the same time,but the peak phase of secretion was unsynchronous,i.e.,in early stage mainly IFN, in recovery stage mainly IL-2. The results suggest that RV infection can stimulate IFN system. IFN may be the most important immune protective factor in early stage.

关 键 词：轮状病毒 胃肠炎 干扰素 儿童 

分 类 号：R512.5[医药卫生—内科学]