前S1抗体反映肝细胞损伤和病毒清除  

Anti-PreS1 Reflects both the Hepatocellular injury and virus Clearance

作　　者：李秀惠[1] 骆抗先[1] 田琦琦 黄已实[1] 

机构地区：[1]广州南方医院,北京佑安医院,石家庄260医院,广州市传染病医院

出　　处：《中华实验和临床病毒学杂志》1994年第2期120-122,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：用前Ｓ１合成肽作试剂（抗原）建立一种酶免疫法，检测各型乙型肝炎病毒（ＨＢＶ）感染系列血清。前Ｓ１抗体检出率在急性乙型肝炎为１００％，慢性活动型肝炎８０％，无症状ＨＢＶ携带者３０％，前Ｓ１抗体在ＨＢｓＡｇ阴转、抗－ＨＢｅ血清转换之前和之后分别为１０．５％和５０％，有显著性升高。各型感染的前Ｓ１抗体检出率与血清丙氨酸转氨酶水平相关。结果提示：前Ｓ１抗体较常出现在肝脏炎症活动时，并在清除ＨＢＶ中增高。因此，前引抗体可反映肝细胞损伤和病毒清除。In order to elucidate the clinical siginicance of anti-preS1 antibody,an enzyme immunoassay (EIA) was developed using a synthetic peptide analogue of presl protein as reagent antigen for testing a different categories of HBV infected patients.The prevalence of anti-preS1 was 100% in acute hepatitis B, 81% in chronic active hepatitis and 30% in asymptomatic HBV carriers,respectively. Anti-preS1 was detected in 10.5% of both HBsAg and HBeAg positive and 50% of anti-HBe-positive and HBsAg negetive asympotmatic HBV carriers,and it was statistically significant.The prevalence of anti-preS1 in AH and CAH were correlated with the increased levels of ALT.The results indicate that anti-preS1 is an earlier antibody of HBV infection.It more often appears in the above liver disease and increased during virus clearance.So,anti-preS1 may reflect both hepatocellular injury and HBV clearance.

关 键 词：前S1抗体 乙型肝炎病毒 感染 

分 类 号：R512.620.3[医药卫生—内科学]