输血后丙型肝炎病毒血症、抗体及转氨酶动态研究  

A Dynamic Study on Hepatitis C Viraemia, Antibody and Alanine Transminase

作　　者：徐东刚[1] 孟宗达 逯好英[1] 马贤凯[1] 孙德贵 刘彩云 牛建章 田茶 陈淑芬 孙永德 

机构地区：[1]河北省卫生防疫站,军事医学科学院三所三室,河北省固安县卫生防疫站

出　　处：《中华实验和临床病毒学杂志》1994年第4期340-343,共4页Chinese Journal of Experimental and Clinical Virology

基　　金：国家科委"八五"河北省卫生厅及省科委资助

摘　　要：对１０例输血后丙型肝炎进行了病毒血症、抗体及丙氨酸转氨酶（ＡＬＴ）动态研究。用套式ＰＣＲ法检测丙型肝炎病毒（ＨＣＶ）ＲＮＡ，首次检出时间为输血后１５～８７天，平均４０．３±２０．１天，持续或间歇阳性超过１年者７例。抗ＨＣＶＣ１００．Ｎ１４、Ｐ２２和ＳｃＮＳ３／４和５抗体首次阳转时间分别为输血后３３～４３７（１１９．７±１１９．５）天、５２～１６６（７７．９±３５．６）天、３３～１０３（５５．０±２３．８）天和３３～６６（４０．１±１３．５）天，该４种抗体阳转后都持续１年以上。ＡＬＴ首次异常时间为输血后１５～６０天，平均３７．９±１３．９天，异常超过１年者６例。A dynamic study on 10 cases of post transfusion hepatitis C viraemia, antibody and alanine transminase was carried out.The positive HCV RNA was first detected at 15-87 days, by 'nested'PCR, with an average of 40.3±20.1 days after transfusion,and sustained and intermitted positive more than one year in 7 cases. Sero positive conversion of anti-HCV C100-3,N14,P22 and Sc NS3/4.5 were at 33-437 (119.7 ±119.5)days,52-166(77.9±35.6)days,33-103(55.0±23.8) days and 33-60(40.1±13.5)days, after transfusion, respectively, and all 4 anti-HCV persisted for more than one year once they became positive.The abnormal ALT was first detected at 15-60 days,with an average of 37.9±13.9 days after transfusion, and persisted for more than one year in 6 cases.

关 键 词：丙型肝炎 丙型肝炎病毒 抗体 转氨酶 病毒血症 

分 类 号：R512.630.2[医药卫生—内科学]