重型病毒性肝炎中丁型肝炎病毒的检测  

Studies on Hepatitis D Virus infection in Fulminant Hepatitis B Patients

作　　者：黄德庄[1] 王全颖[1] 贺丽香[1] 李蜀南 闽福援 魏晓清[1] 庄辉[1] 

机构地区：[1]北京佑安医院肝炎研究所,北京医科大学公共卫生学院

出　　处：《中华实验和临床病毒学杂志》1994年第4期336-339,共4页Chinese Journal of Experimental and Clinical Virology

摘　　要：为了探讨丁型肝炎病毒（ＨＤＶ）感染在重型病毒性肝炎中的作用，对北京佑安医院１９８０年至１９８９年收治的５４例急性和亚急性重型肝炎和３８例急性乙肝患者血清，应用国产ＨＤＶＥＬＩＳＡ试剂测定抗－ＨＤ、抗－ＨＤＩｇＭ和ＨＤＡｇ，应用斑点杂交技术测定ＨＤＶＲＮＡ。结果发现重型肝炎组ＨＯＶ－Ｍ检出率明显高于急性乙肝组（２７．８％比５．３％．Ｐ＜０．０５）。单独ＨＢＶ感染和ＨＤＶ／ＨＢＶ混合感染的重型肝炎患者均有较高的病死率。提示ＨＤＶ感染是重型肝炎中重要的病原学因素之一，ＨＤＶ与ＨＢＶ具有协同作用加重肝损害，导致肝衰竭。In order to explore the role of HDV infection in fulminant hepatitis B, 54 patients with fulminant hepatitis B and 38 patients with acute hepatitis B were stuided for prevalence of anti-HD, anti-HD IgM and HDAg in serum with ELISA,and HDV RNA by dot- blot hybridization.The positive rates of HDV markers were significantly higher in fulminant hepatitis B than those in acute hepatitis B (27.8% vs 5.3% P<0.05).The positive rate of HDV RNA was 20.4%(11/54).The mortalities were both high in simple HBV group (51.3%)and HDV/HBV group 33.3%.The results showed that HB associated with HDV infection usually aggravated the liver lesion and more often promoted the development of liver failure.

关 键 词：丁型肝炎病毒 重型肝炎 病毒性肝炎 

分 类 号：R512.630.4[医药卫生—内科学] R373.21[医药卫生—临床医学]