灌洗量对移植用犬肾的影响  

The influence of perfusion volume on thecanine kidney for transplantation

作　　者：谷艳丽[1] 曹凡军 张肖红[1] 鄢业鸿[1] 马淑娴[1] 王虹[1] 郭晖[1] 夏穗生[1] 

机构地区：[1]洛阳医学高等专科学校附属医院泌尿外科,同济医科大学器官移植研究所,海南省人民医院泌尿外科

出　　处：《中华实验外科杂志》1994年第3期135-136,共2页Chinese Journal of Experimental Surgery

摘　　要：我们以３０条大为研究对象，肾脏切除后分组用不同量的保存液进行道洗，并设不灌洗一组，保存２４小时后自体移植，观察恢复血而后１小时菊粉清除率（Ｃｉｎ），肾小管相对钠重吸收率（ＦＲｎａ）等早期肾功能及术后血肌酐（Ｃｒ）恢复情况。结果各项指标以不灌洗组及灌洗３ｍｌ／ｇ～４ｍｌ／ｇ组为佳，并从组织学角度进一步证实了灌洗损伤的存在和形成机制。The donor kidney is usually flushed withcold solution by a vascular route when har-vested.this procedure can make the kidneycool immediately and preserve for longer time.But the perfusion-related injuries may occur when the kidney is over-perfused.The purposeof this study is to find the optimal perfusionvolume. In this paper,the influence of differ-ent perfusion volume on the initial and long-term graft function were compared,and themorphological changes were studied.The re-sults showed that:(1)The initial.perfusionvolume can influence the function of the trans-planted kidney.(2)Perfusion volume of 3～4ml/g is optimal,more than 8ml/g,can causethe perfusion-related injuries in canine donorkidney, and more than 15ml/g,the injuries aremuch more serious.(3)The unperfused caninekidneys can be safely preserved at 0～4℃for24 hours.

关 键 词：肾移植 灌洗量 灌洗损伤 

分 类 号：R699.2[医药卫生—泌尿科学]