模拟受体聚合物的合成及吸附行为研究  

Synthesis of Receptor Mimicking Polymers and Their Adsorption Behavior

作　　者：何建峰[1] 刘岚[1] 林秋明[2] 邓芹英[1] 

机构地区：[1]中山大学化学与化学工程学院,广东广州510275 [2]佛山教育学院化学系,广东佛山528000

出　　处：《分析测试学报》2005年第3期6-9,共4页Journal of Instrumental Analysis

基　　金：国家自然科学基金资助项目(20202015);国家教育部博士点基金资助项目(20020558026)

摘　　要：采用紫外光引发聚合的分子印迹技术,分别制备阿替洛尔、美托洛尔、尼莫地平、酮糠唑4种模板化合物的分子印迹聚合物(molecularlyimprintedpolymers,MIP)。利用紫外平衡吸附法研究了聚合物的吸附性能和选择识别能力。结果表明,阿替洛尔、美托洛尔印迹聚合物对各自的模板分子呈现良好的再识别性能,而尼莫地平、酮糠唑印迹聚合物对原模板则几乎没有识别能力。Scatchard分析显示了功能单体甲基丙烯酸(MAA)与模板分子阿替洛尔、美托洛尔在自组装过程中通过氢键和离子键形成了至少两类不等价的结合位点。对底物交叉结合实验也表明阿替洛尔、美托洛尔这两种印迹聚合物具有良好的选择性,分离因子α值分别达到了1.75和1.62,而空白聚合物则分别仅为1.07和0.97。Four types of molecularly imprinted polymers(MIP)were synthesized using atenolol,metoprolol,nimodipine and ketoconazole as template molecules through a molecular imprinting technique.The adsorption properties and selectivity ability of MIP were studied with UV equilibrium adsorption procedures.The results suggested that atenolol and metoprolol imprinted polymers exhibited a good rebinding ability for the template,whereas nimodipine and ketoconazole polymers showed almostno rebindingadsorption.Scatchard analysis indiˉcated that at least two different classes of recognition sites were formed during the course of self_assembly beˉtween monomers and templates through hydrogen bond or ionic bond.The crossed binding experiment for difˉferent substrates showed that atenolol and metoprolol imprinted polymers possessed excellent selectivity toˉward the template compared to the analogs.The values of the separation factorαof atenolol and metoprolol imprinted polymers reached1.75and1.62,and whereas theαvalues of corresponding blank polymers were only1.07and0.97.

关 键 词：分子印迹聚合物 模板 Scatchard分析 阿替洛尔 美托洛尔 

分 类 号：O657.32[理学—分析化学]