Losec治疗食管源胸痛止痛效果的评价  

EVALUATION OF THE EFFICACY OF LOSEC IN RELIEVING ESOPHAGEAL CHEST PAIN

作　　者：罗金燕[1] 王进海[1] 龚均[1] 朱有玲[1] 

机构地区：[1]西安医科大学第二医院

出　　处：《中华消化杂志》1994年第1期18-20,共3页Chinese Journal of Digestion

摘　　要：应用洛赛克（Ｌｏｓｅｃ２０ｍｇ／ｄ）对７８例食管源胸痛进行了止痛效果的临床观察，全部患者经内镜，食管测压，酸反流试验等形态学和动力学检查诊断。研究结果表明：Ｌｏｓｅｃ对各种原因引起的食管源胸痛均有明显的止痛效果，总有效率为８２．１％；与硝苯啶联合服用对由高张力型食管运动障碍引起的胸痛止痛有效率为７４．１％，明显高于单用硝苯啶组３６．８％（Ｐ＜０．０５）。total of 78 patients with esophageal chest pain were treated with Losec(20 mg oncedaily),including GER(18),GERD(n=24),achalasia(5),iffuse esophageal spasm(DES,n=5),hypertensive lower esophageal sphincter(HLES,n=6),presbyesophagus (n=5),esophagealcarcinoma(n=9) and others(n=8). 40 patients with hyperdyskinesia of esophageal motilitywere divided at random to either Losec 20mg once daily plus Nifedipinum l0mg thrice dailyor Nifedipinum l0mg thrice daily.The results showed that Losec was efficacious for relievingthe chest pain caused by esophageal diseases, the total pain relieving rate being 8.1%.Among them,the pain relieving rates were 88.9%in GER, 87.5%in GERD, 66.1% inachalasia,80% in DES,50% in HLES,80% in presbyesopagus and 88.9% in esophagealcarcinoma.The pain relieving rates were 74.1% in Losec plus Nifedipinum and 36.8% inNifedipinum alone(P<0.05).

关 键 词：食管源胸痛 洛赛克 药理学 

分 类 号：R975[医药卫生—药品]