小儿肝炎后肝硬化肝脏病理学研究  

LIVER PATHOLOGICAL STUDY ONPOST- HEPATIC CIRRHOSISIN CHILDHOOD

作　　者：李关汉[1] 段恕诚[1] 胡锡琪 朱启镕 顾静安[1] 陈莲[1] 

机构地区：[1]上海医科大学儿科医院

出　　处：《中华消化杂志》1994年第6期330-332,共3页Chinese Journal of Digestion

摘　　要：为了解小儿肝炎后肝硬化的肝脏病理学特点以及同乙型肝炎病毒（ＨＢＶ）感染的关系，对本院１９５６～１９９１年共３５年间确诊的３８例小儿肝炎后肝硬化病例进行了肝脏病理学研究和肝内ＨＢＶ抗原检测。结果发现，本组病例活动性肝硬化占８９．５％；肝内卵圆细胞增生活跃，并与肝硬化活动程度关系密切（Ｐ＝０．０２），但与患儿年龄无明显相关；肝内ＨＢｓＡｇ阳性率８６．７％，ＨＢｃＡｇ阳性率６６．７％，两抗原总阳性率９３．３％。本研究表明：（１）小儿肝炎后肝硬化以活动性肝硬化多见，可能与大多数患儿肝内ＨＢＶ尚未清除有关；（２）卵圆细胞增生对肝损伤的修复有重要意义；（３）我国小儿肝炎后肝硬化绝大多数为乙型肝炎后肝硬化。To determine the pathological feature of post-hepatic cirrhosis and the relation betweencirrhosis and hepatitis B in childhood,we reviewed the liver speciments of 38 children withpost-hepatic cirrhosis selected from our hospital during l956～1991, and examined HBV antigens inliver.89.5%of the patients were those with active cirrhosis。Oval cells proliferated markedly inthe liver and were closely associated with the degree of hepatic injury(p=0.02),but not with theirage.The positive rates of HBsAg and HBcAg in liver were 86.7%and 66.7%,respectively,and theoverall positive rate of two antigens was 93.3%.Finally,we conclude that the high proportion ofactive cirrhosis is probably due to the existence of hepatitis B virus(HBV)in most of childrenwith post-hepatic cirrhosis,and that the proliferation of oval cells is beneficial to the recovery ofhepatic injury,and that most of these patients were due to hepatitis B.

关 键 词：肝炎后 肝硬变 卵圆细胞 乙型肝炎病毒 抗原 

分 类 号：R725.75[医药卫生—儿科]