8 Hz、90 dB次声引起的心肌细胞超微结构变化及相关机制的探讨  

Effects of infrasound on the ultra-structure of rat myocardium

作　　者：裴兆辉[1] 陈景藻[2] 朱妙章[1] 裴建明[1] 庄志强[2] 刘静[3] 

机构地区：[1]第四军医大学基础部生理学教研室 [2]第四军医大学预防医学系 [3]第四军医大学西京医院理疗与康复科,陕西西安710032

出　　处：《心脏杂志》2005年第3期216-217,共2页Chinese Heart Journal

基　　金：军队"十五"指令性课题(01L071)

摘　　要：目的:观察次声多次暴露后大鼠心肌细胞超微结构的变化,并分析其机制。方法:用8Hz、90dB的次声连续作用大鼠1、7、14、21和28d,每天2h,使用透射电镜观察心肌细胞超微结构改变。结果:在次声暴露期间,与对照组比较,1d无显著变化,7d开始出现少数线粒体肿胀,14d开始出现较多线粒体肿胀,21d肌浆网扩张,28d有血栓形成。结论:8Hz、90dB次声可引起心肌细胞超微结构的轻微变化,这些变化和次声暴露时间和量有关。AIM: To observe the changes in ultra-structure of rat myocardium. METHODS: The rats were exposed to the infrasound with 8 Hz and 90 dB, for 1,7,14,21 and 28 d, 2 h daily, and the ultra-structure of rat myocardium were observed under the transmlssion electron microscope. RESULTS: Changes in ultra-structure of myocardium were compared with those of the control groups. There were no significant changes in the 1 d group and dilated endoplasmic reticulum and swollen mitochondrias occasionally appeared in the 7 d group. In the 14 d group, there were relatively more swollen mitochondrias and in the 21 d group,more mitochondrias and dilated sarcoplasmic reticulum were observed. In the 28 d groups,even more swollen mitochondrias and dilate sarcoplasmic reticulum were seen. CONCLUSION: Infrasound can damage the ultra-structure of myocardium, which were seen related with the time of infrasound exposare an appeared d the level of sound pressure.

关 键 词：次声 大鼠 超微结构 心肌细胞 

分 类 号：Q463[生物学—生理学]