血小板活化在不稳定性心绞痛中的意义  

The significance of platelet activation in unstable angina

作　　者：潘宜智[1] 吾柏铭[1] 洪小苏[1] 张莉丽[1] 刘励军[1] 陈建昌[1] 高岚[1] 

机构地区：[1]苏州医学院附属第二医院心内科,广州市第一人民医院

出　　处：《中华心血管病杂志》1994年第4期247-248,共2页Chinese Journal of Cardiology

摘　　要：应用放免法测定３０例不稳定性心绞痛（ＵＡ）、２９例稳定性心绞痛（ＳＡ）患者和２０例正常人血小板膜表面α－颗粒膜蛋白（ＧＭＰ－１４０）分子数和血浆血栓素Ｂ２（ＴＸＢ２）浓度，结果显示，ＵＡ患者心绞痛发作时血小板膜表面ＧＭＰ－１４０及血浆ＴＸＢ２明显高于ＳＡ患者心绞痛发作时和正常对照组，后两者间差异无显著性。心绞痛终止后３０分钟，升高的ＧＭＰ－１４０全部恢复至正常组水平。ＧＭＰ－１４０显著增高者，易发生心肌梗塞和心脏性猝死。提示血小板活化在ＵＡ的发生和发展中具重要意义。Abstract The value of alpha-granule membrane protein (GMP-140) on the surface of platelet and serum TXB2 were determined in 30 patients with unstable angina (UA),29 patients with stable angina (SA) and 20 normal subjects by RIA. The results showed that GMP-140 molecules on the platelet surface and serum TXB2 in UA patients were markedly higher than those in SA patients when angina episoded and those in control.There were no divergences in the value of GMP-140 and TXB2 between SA and control. Increased GMP-140 declined to the level of control 30 minutes after relief of angina. There was some correlation between the increase of MI and sudden death and the level of GMP-140 molecules on the platelet surface. The result indicates that platelet activation played an important role in the pathogenesis and progress of UA.

关 键 词：心绞痛 血小板 膜蛋白 血栓素B2 

分 类 号：R541.4[医药卫生—心血管疾病]