慢性染铅对小鼠血铅、脑铅含量及海马超微结构变化的影响  

Effect of lead exposure on the concentrations of blood lead and brain lead in mice and the related microstructural changes in hippocampus

作　　者：张天彪[1] 高明奇[2] 孙黎光[1] 刘晓梅 赵滢[3] 

机构地区：[1]中国医科大学基础医学院生物化学与分子生物学教研室,辽宁沈阳110001 [2]中国医科大学基础医学院机能实验中心 [3]中国医科大学附属第二医院普外三科

出　　处：《中国医科大学学报》2005年第3期195-196,共2页Journal of China Medical University

基　　金：国家自然科学基金资助项目(39970651)

摘　　要：目的:研究脑发育早期低水平铅暴露通过母体对仔鼠血铅、脑铅含量及海马超微结构变化的影响。方法:石墨炉原子吸收仪测定不同浓度低水平铅暴露后的小鼠子代的血铅、脑铅含量,电镜观察海马超微结构。结果:各组仔鼠随着铅暴露水平的增加,血铅、脑铅含量也都相应增加,均高于对照组(P<0.05)。海马超微结构发生改变。结论:低水平铅暴露对脑的功能产生损伤,改变海马超微结构,并可持续至成年阶段。提示孕母及婴儿是铅暴露的高危人群,铅可由母体传递给子代。Objective: To investigate the concentrations of blood lead and brain lead in mice and the microstructural changes in hippocampus after maternal exposure to different concentrations of lead during early developmental stages. Methods: Polarized zeem atomic absorption spectrophotometer and electron microscopy were used. Results: The concentrations of blood lead and brain lead in mice of all experimental groups were higher than those in the control group, which showed a dose-response effect. Electron microscopy demonstrated that the microstructure have changed in the region of hippocampus. Conclusion: After maternal exposure to low and different concentrations of lead, the ability of brain could be damaged. The microstructure changed and up to the adult period. Pregnant women and infants are high-risk population. Lead could be transferred to offspring from maternity.

关 键 词：铅 海马 血脑屏障 超微结构 

分 类 号：R135.1[医药卫生—劳动卫生]