骨髓增生异常综合征及其继发白血病的治疗  

STUDIES OF BONE MARROW BLAST CELLPROGENITORS OF MYELODYSPLASTIC SYNDROMES INCULTURE

作　　者：张新友 郝玉书 邵宗鸿 徐肇明 钱林生 

机构地区：[1]中国医学科学院协和医科大学血液病医院,深圳市人民医院

出　　处：《中华血液学杂志》1994年第7期349-352,共4页Chinese Journal of Hematology

摘　　要：报告常规剂量联合化疗治疗骨髓增生异常综合征（ＭＤＳ）及其继发性急性髓系白血病（ＳＡＭＬ）１７例，完全缓解率３５％，部分缓解率１２％，总有效率４７％。证明对ＭＤＳ患者有选择性地采用常规剂量联合化疗是可行的。此外，还对化疗期间骨髓变化过程及毒副反应进行了观察。he in vitro growth of bone marrow blast cellprogenitors (BCP) was studied in 27 patients withmyelodysplastic syndromes (MDS). The bone marrowmononuclear cells used in cultures were deprived of T-lymphocytes and monocytes, and phytohemagglutininleukocytes-conditioned medium (PHA-LCM) was usedas stimulator. Blast cell colonies (BCC) were found in10 (37%) out of 27 MDS patients. There weresomewhat relationships between BCC growth and MDSsubtypes. The BCC growth rates correlated significantlywith sister chromatid differentiation. No BCC wasobserved in the controls. Our results showed that theBCP might reflect the malignant clone in MDS, andBCC be an important index to evaluate the disease stageof MDS.

关 键 词：骨髓增生异常 白血病 药物疗法 

分 类 号：R551.305[医药卫生—血液循环系统疾病]