HLA－B51与中国北方汉族中的白塞氏病相关联  

HLA-B51 ASSOCIATED WITH BEHCET'S DISEASE IN NORTHERN HAN CHINESE

作　　者：田丁[1] 峰下哲[1] 王黎曼 李世荫[1] 冯高章 边天羽 廖海孙 姜学义 田中平三 佐久间昭 

机构地区：[1]首都医科大学宣武医院,东京医科齿科大学难治疾患研究所,天津中西医结合皮肤病研究所,北京医科大学第三医院,哈尔滨医科大学二院

出　　处：《中华医学遗传学杂志》1994年第5期261-263,共3页Chinese Journal of Medical Genetics

基　　金：日本教育部基金

摘　　要：对１２０例白塞氏病患者和１００名无关健康人进行了ＨＬＡ－Ａ、－Ｂ、－Ｃ、－ＤＲ和－ＤＱ抗原分型检测，并使用Ｌｙｍｐｈｏ－Ｂ－Ｋｗｉｋ分离出Ｂ－淋巴细胞进行ＨＬＡ－ＤＱ和－ＤＲ分型，用琼脂糖电泳，免疫固定等技术测定了Ｂｆ和Ｃ４同种异型。其中，５５．８３％（６７／１２０）患者中检出ＨＬＡ－Ｂ５１，而对照组仅１２％。Ｘ２和ＲＲ分别为４５．５４和９．２７（Ｐ＜０．０００５）．完全型组ＨＬＡ－Ｂ５１更为常见（６２．７９％）；除患者组的Ｃ４ＡＱ０明显高于对照组外，其它的ＨＬＡ抗原、Ｂｆ和Ｃ４同种异型无明显的组间差异。结果提示：某些内在因素，诸如免疫遗传背景（存在有与ＨＬＡ－Ｂ５１密切相关的ＢＤ易感基因）在其病因及发病机理中可能起着重要作用。One hundred and twenty patients suffering from Behcet' s disease and 100 unrelative healthy individuals, all being Han nationality Chinese and living in the northern area of Yellow River, were typed for HLA-A,B, C and DR, DQ antigens, The HLA-sera were provided by 11th-IHWC(set 2 or set 1).HLA-DR and -DQ typing was performed on B-lymphocyte separated with Lympho-B-KwiK. Bf alleles and C4 allotypes were determined by immnofixation electrophoresis.HLA-B51 was found in 67/120(55. 83%) patients and in 12/100(12%) controls, the relative risk and chi-square values being 4. 72 and 17.6 3 respectively(P<0.0005). In the complete form patients,HLA-B51 was observed more frequently(62.79%). No significant differences of other HLA antigens,Bf and C4 alleles were found between the groups.

关 键 词：白塞病 人白细胞抗原 汉族 

分 类 号：R597.903[医药卫生—内科学]